In today’s episode, I sat down with Rajeev Kapur, an AI expert and author of AI Made Simple, to explore the rapidly evolving role of AI in medicine. We dive into how AI is enhancing diagnostics, optimizing treatment plans, and helping patients take control of their own health data.

We also break down common fears and misconceptions—will AI replace doctors? Can we trust AI-powered medical advice? How can everyday people use AI tools to improve their health outcomes?

Rajeev Kapur is a leading voice in AI education and its applications in healthcare. As an author, speaker, and technology strategist, he specializes in making AI accessible and practical for both professionals and the general public. His work focuses on bridging the gap between cutting-edge technology and real-world healthcare solutions.

Whether you're a healthcare professional curious about AI’s future or someone looking for ways to use AI to optimize your own health, this episode is packed with essential insights.

We Also Discuss: 

• Exploring AI in Healthcare Integration
• Empowering Healthcare Education With AI
• Personalized Healthcare Coaching With AI
• Advancements in Longevity and Wellness
• AI Enhancing Healthcare Conversations
• Beginner's Guide to AI Basics

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Dr. Rajeev Kapur 

Instagram: therajeevkapurWebsite: https://rajeev.ai/ Book: AI Made Simple 

Bone health is often overlooked until a fracture happens—but by then, the damage has already been done. What most people don’t realize is that bones are not just structural; they play a critical role in metabolism, hormone regulation, and long-term vitality. In fact, emerging research shows that osteoporosis and bone loss start much earlier than expected, even in people in their 30s and 40s. So how can you build and maintain strong bones that support your health for a lifetime?

In this episode, we uncover the hidden endocrine role of bones, how they influence everything from testosterone to brain function, and why strength training is essential—not just for muscle, but for bone density and metabolic health. We also explore the early warning signs of osteoporosis (including in young adults), the overlooked lifestyle factors that accelerate bone loss, and the latest breakthroughs in hormone therapy for skeletal strength.

To guide us through the science, I’m joined by Dr. Vonda Wright, an orthopedic surgeon, author, and longevity expert specializing in musculoskeletal health. With decades of experience treating elite athletes, weekend warriors, and aging populations, Dr. Wright is redefining how we think about movement, mobility, and skeletal longevity.

If you want to future-proof your bones, prevent fractures, and stay strong well into old age, this episode is packed with insights you won’t want to miss.

We Also Discuss:

(00:00) Doctors Discuss Health, Longevity, and Teaching

(09:28) Revolutionizing Healthcare and Education

(16:25) The Astonishing Role of Bones

(31:06) Functional Movement and Mobility Training

(44:05) Optimizing Bone Health Through the Lifespan

(58:15) Optimizing Health Through Science and Hormones

(01:12:11) Measuring Senescent Cells and Longevity

(01:26:30) Anticipation for Upcoming Book Launch

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Dr. Vonda Wright

Website: https://www.drvondawright.com Instagram: https://www.instagram.com/drvondawright Facebook: https://www.facebook.com/DrVondaWright

What if the symptoms you've been chalking up to "normal life"—brain fog, persistent insomnia, chronic fatigue, and the stubborn belly fat—were actually signs of a deeper disconnection from what makes us truly human?

In this episode, I sit down with Jeff Krasno, author of "Good Stress: The Health Benefits of Doing Hard Things," to explore the hidden epidemic of disconnection and its profound impact on our health. We dive into why social isolation is as harmful as smoking 15 cigarettes daily, how community might be the #1 factor in longevity according to Harvard's 85-year study, and practical strategies for rebuilding "social fitness" in an increasingly isolated world.

Jeff shares his personal journey from successful wellness entrepreneur to burnout victim—running a yoga festival while suffering from insomnia, pre-diabetes, and deep disconnection. His story reveals how the modern lifestyle can lead anyone into what he calls "wealth and hellness" instead of health and wellness.

Jeff is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being. He hosts the Commune podcast, interviewing a wide variety of health experts and luminaries from Andrew Huberman and Marianne Williamson to Matthew McConaughey and Gabor Maté. Jeff pens a personal weekly essay titled “Commusings” that explores spirituality, wellness and culture and is distributed to over one million subscribers every Sunday. Jeff is the author of Good Stress, a collection of wellness protocols that he developed to reverse his diabetes, lose 60 pounds and reclaim his health at age 50.

We Discuss:

(01:00) - Belonging, Community, and Loneliness

(14:34) - Social Connection and Introversion

(25:53) - Health Crisis in Modern Society

(33:22) - Navigating Burnout and Stress Responses

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Jeff Krasno: 

Website: https://www.jeffkrasno.com/ 

Instagram: @jeffkrasno

Thank You To Our Sponsors: 

• Deliverance: Give your liver the care it deserves! Deliverance is a powerful plant-based formula designed to support and restore liver health. Get 10% off your first order with code DRSHAH at loveyourliver.com

• Timeline: Upgrade your energy from within! Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah

We often hear about the latest treatments for chronic disease, but what if you could prevent these conditions before they even begin? The truth is, most of the top 10 causes of death are entirely preventable, yet our healthcare system focuses on treating disease rather than stopping it in its tracks.

In today’s episode of Extend, I’m breaking down the science of preventative medicine, and how you can take control of your health before disease takes control of you. Most chronic diseases don’t happen overnight; they develop over years of silent damage. But by understanding early warning signs and risk factors, you can intervene before these conditions ever take hold.

We’ll explore how cardiovascular disease is the common denominator behind multiple causes of death, including heart disease, stroke, and kidney failure. You’ll learn why metabolic dysfunction plays a hidden role in everything from diabetes to Alzheimer’s. Plus, we’ll discuss why early cancer detection is the #1 factor in survival rates, and how improving your immune health can make all the difference.

And beyond chronic disease, I’ll dive into something most doctors never talk about… accidental injuries. Falls, car accidents, and drug overdoses are responsible for thousands of preventable deaths each year, but small lifestyle adjustments can dramatically reduce your risk.

If you’re serious about living longer and better, this episode is a must-listen. Prevention is the key to longevity, let’s dive in!

I also discuss:

• Preventative Medicine

• The 10 Leading Causes of Death and Why They’re Preventable

• The Role of Cardiovascular Health in Chronic Disease

• Early Cancer Detection: The Key to Survival

• Preventing Accidents & Chronic Diseases

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Fasting has been praised as a powerful tool for weight loss, metabolic health, and longevity, but is it always beneficial? The truth is, fasting can either optimize your biology or work against you, depending on how, when, and for how long you do it. Research now suggests that skipping breakfast, a common intermittent fasting practice, is linked to higher cardiovascular risk and increased mortality. At the same time, strategic fasting has been shown to trigger cellular regeneration, reduce inflammation, and even reverse certain disease markers. So, how do you get it right?

In this episode, we break down the biggest mistakes people make with fasting, the science of fasting-induced repair mechanisms, and the critical role of refeeding in longevity. We also dive into the controversy around high-protein diets, how different macronutrients impact aging, and why a personalized approach to nutrition is essential for long-term health.

To guide us through the latest research, I’m joined by Dr. Valter Longo, a globally recognized expert on longevity and nutrition. As a professor at USC and director of the Longevity Institute, his groundbreaking work on fasting and aging has reshaped how we understand diet and disease prevention. His research led to the development of the Fasting-Mimicking Diet, a clinically tested approach designed to harness the benefits of fasting while maintaining proper nourishment.

Let’s get into it.

We Also Discuss:

01:41 - 03:33 – The Biggest Mistakes People Make with Fasting

07:32 - 08:44 – Personalizing Your Diet for Longevity

18:26 - 20:30 – How Processed Foods & Starches Impact Your Metabolism

25:51 - 26:36 – The Hidden Dangers of Excess Protein

31:54 - 33:47 – The Right Way to Think About Fats

40:22 - 41:49 – How Fasting Triggers Self-Repair Mechanisms

46:39 - 48:32 – Fasting vs. GLP-1 Drugs—What’s Better for Metabolic Health?

47:33 - 01:38 – Can Fasting Reverse Biological Age?

Thank You to Our Sponsors:

• TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/

• IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/

• Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/

• Vitaboom: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Dr. Valter Longo

Website: https://valterlongo.com/welcome/

Instagram: https://www.instagram.com/prof_valterlongo/

Facebook: https://www.facebook.com/@profvalterlongo/

What if the symptoms you’ve been chalking up to aging, low energy, brain fog, stubborn belly fat, and lack of motivation, were actually signs of a deeper hormonal imbalance? 

The truth is, testosterone levels in men have been plummeting for decades, and it’s not just about aging. Environmental toxins, chronic stress, poor sleep, and nutrient deficiencies are creating a perfect storm for hormonal disruption, affecting not only performance but long-term health and longevity.

In today’s episode, I sat down with Dr. Tracy Gapin, a board-certified urologist and expert in men’s health optimization, to break down the science of testosterone, hormone balance, and high-performance living. We dive into why traditional medicine is failing men, how environmental toxins are silently crushing testosterone levels across generations, and the critical role of biomarker testing in personalizing health strategies.

Dr. Tracy Gapin is a board-certified urologist with 23 years of clinical experience in men's health, functional medicine, and longevity. As the founder of the Gapin Institute and author of Male 2.0, he specializes in precision health, leveraging genetics, epigenetics, and advanced diagnostics to optimize performance and extend healthspan.

We Also Discuss:

00:00 - Introduction to Men's Health and Hormones

02:15 - Significance of Testosterone in Men's Health

05:30 - Limitations of Traditional Healthcare in Addressing Men's Health Issues

08:45 - Understanding Underlying Reasons for Health Concerns

12:00 - Comprehensive Biomarker Testing for Health Optimization

15:20 - Impact of Lifestyle Factors (Nutrition, Stress) on Hormone Levels

18:35 - Effects of Environmental Toxins on Testosterone Levels and Overall Health

22:10 - Distinction Between Total Testosterone and Free Testosterone

25:45 - Relevance of Testosterone for Both Men and Women

29:00 - Various Methods of Testosterone Therapy (Injectable, Topical, Pellets)

32:30 - Management and Necessity of Regular Testing in Hormone Therapy

35:50 - Personalized Approaches to Hormone Therapy

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Dr. Tracy Gapin: 

Website: https://drtracygapin.com/ https://gapininstitute.com/start-here-gapin/

Instagram: https://www.instagram.com/drtracygapin/

Thank You To Our Sponsors: 

• Deliverance: Give your liver the care it deserves! Deliverance is a powerful plant-based formula designed to support and restore liver health. Get 10% off your first order with code DRSHAH at loveyourliver.com
• Timeline: Upgrade your energy from within! Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah

Have you ever wondered why gut health is at the root of everything, from metabolism and cravings to immunity and even mental clarity?

Why do some people struggle with weight gain, energy crashes, and digestive issues despite eating well? And could the rise of GLP-1 medications like Ozempic be a sign that we’ve been ignoring a natural solution all along?

In today’s episode of Extend, I’m joined by Colleen Cutcliffe, a microbiome scientist and co-founder of Pendulum, a company leading the way in gut health research. She’s here to break down why your microbiome isn’t just about digestion, it plays a critical role in weight regulation, blood sugar balance, and even hormone production.

We’ll explore how your gut bacteria influence GLP-1, the hormone behind popular weight loss drugs, and why restoring your microbiome may be the key to naturally optimizing metabolism, reducing cravings, and improving long-term health.

If you’ve ever dealt with stubborn weight, gut issues, or unexplained fatigue, this episode will give you science-backed strategies to rebuild your gut health, support natural GLP-1 production, and take control of your metabolism, without relying on injections.

Colleen Cutcliffe, PhD, is a biochemist and microbiome researcher with over 20 years of experience in biotechnology and life sciences. She is the CEO and co-founder of Pendulum, a company pioneering next-generation probiotics to optimize metabolic and gut health.

We Also Discuss:

(00:00) What Is the Microbiome & Why It Matters

(14:40) How Your Skin & Oral Microbiome Affect Overall Health

(33:48) The Gut-GLP-1 Connection: How Your Microbiome Regulates Metabolism

(44:24) How Menopause Transforms Your Gut Microbiome

(51:05) The Gut-Brain Connection: How Your Microbiome Produces Neurotransmitters (58:02) How an Unhealthy Microbiome Leads to Disease

(01:03:51) How to Improve Your Gut Health With Diet & Testing

(01:14:32) The Future of Microbiome Science: Supplements & Targeted Probiotics

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Colleen Cutcliffe:

Website: https://pendulumlife.com/ Instagram: https://www.instagram.com/pendulumlifeco/ 

Instagram: https://www.instagram.com/drcolleencutcliffe/

Thank You to Our Sponsors:

• TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/

• IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/

• Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/

• Vitaboom: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/

What if everything you’ve been told about nutrition is only half the story? It’s not just about avoiding carbs, counting macros, or following the latest health trend—it’s about how food impacts your metabolism, gut, and long-term health on a deeper level. The problem? Most people are stuck in a cycle of restrictive diets, misinformation, and ultra-processed foods that silently sabotage their well-being.

In this episode, I sit down with registered dietitian and longevity expert Ella Davar to break down the science of personalized nutrition. We’ll explore why gut health is the foundation of everything from digestion to mental clarity, how glucose monitoring can help you optimize your diet, and why ultra-processed foods are doing more damage than you realize. Ella shares her journey from Wall Street to wellness and reveals how a bio-individual, data-driven approach to food can help you feel better, think clearer, and age stronger.

Ella Davar is a registered dietitian, gut health expert, and longevity advocate specializing in personalized nutrition. She is also the author of The Guide to a Euterian Diet and the founder of The Gut-Brain Method, a program designed to help people harness the power of food to improve cognitive function, energy levels, and longevity.

If you’re ready to improve your energy, digestion, and overall health, this episode is for you. Let’s get started.

We Also Discuss:

(00:38) The Problem with Modern Dieting & Why Most People Struggle

(04:18) Why Food Is Medicine & How It Transforms Your Health

(09:48) Gut Health 101: The Key to Energy, Mood & Metabolism

(16:27) How to Use CGM & Stool Testing for Personalized Nutrition

(22:13) The Truth About Ultra-Processed Foods & Their Impact on Health

(29:02) Bio-Individuality: Why There’s No One-Size-Fits-All Diet

Thank You To Our Sponsors: 

Deliverance: Give your liver the care it deserves! Deliverance is a powerful plant-based formula designed to support and restore liver health. Get 10% off your first order with code DRSHAH at loveyourliver.com

Timeline: Upgrade your energy from within! Timeline helps power up your cells, supporting muscle strength, mental clarity, and overall vitality. Stay active, sharp, and strong at any age! Claim 10% off your first order now at timeline.com/DrShah

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn More about Ella Davar:

Website: https://www.gutbrainmethod.com/

Instagram: https://www.instagram.com/ella.davar/ 

Sleep isn't just about rest, it's a critical pillar of metabolic health, cognitive function, and longevity. In this solo episode of Extend, I dive deep into the science of sleep routines and circadian rhythms. I share how proper sleep habits are foundational to the new healthcare paradigm focused on vitality rather than disease management.

I explain that your sleep routine actually begins the moment you wake up and continues throughout your day, not just before bedtime. I also cover relaxation techniques like four-by-four box breathing and supplements that may help sleep quality, though I typically avoid recommending melatonin except for jet lag. Additionally, I address the common issue of nighttime urination disruptions and offer strategies for returning to sleep if you wake up in the middle of the night, including breathwork and non-sleep deep rest protocols.

By implementing these evidence-based techniques consistently, you can transform your sleep quality and overall health. If you're struggling with falling asleep, waking up groggy, or insufficient deep sleep, this episode provides a concrete, step-by-step strategy to build a powerful sleep routine that optimizes your health, longevity, and daily performance.

I Discuss:

03:40 The genetic factors that determine your natural sleep-wake tendencies

05:54 Morning routine strategies to optimize your circadian rhythm

07:37 Evening wind-down practices

09:09 Lifestyle factors affecting sleep quality

11:34 Supplements for sleep and managing common sleep disruptions

13:14 Breathwork and journaling

Studies Cited:

https://academic.oup.com/sleep/article/40/2/zsw048/2662182

https://pubmed.ncbi.nlm.nih.gov/33054339/

Links:

https://sleepdoctor.com/sleep-quizzes/chronotype-quiz

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Have you ever felt like mental health care is stuck in the past?

Why are rates of depression, anxiety, and even conditions like autism skyrocketing in today’s world? And why does traditional treatment often fall short? Spoiler: the answer lies deeper than just brain chemistry… it’s all about your metabolic health.

In this week’s episode of Extend, I’m joined by Dr. Chris Palmer, a psychiatrist and author of Brain Energy. Together, we’re unraveling the powerful connection between your metabolic health and your brain, exploring how poor nutrition, environmental toxins, and lifestyle choices are driving the modern mental health epidemic.

But this isn’t just a conversation about problems, it’s about solutions. Dr. Palmer shares groundbreaking insights into how addressing metabolic dysfunction can lead to dramatic recoveries for people with conditions once thought untreatable, like schizophrenia, bipolar disorder, and severe depression.

Dr. Chris Palmer is a Harvard-trained psychiatrist, researcher, and the author of Brain Energy, a groundbreaking book that challenges conventional views on mental health.His work integrates cutting-edge neuroscience with practical, science-backed strategies to heal the brain through nutrition, lifestyle, and metabolic therapies. 

If you’re ready to transform the way you think about mental health and learn actionable steps to heal from the inside out, this episode will give you the hope and tools you need. Let’s dive in!

We Also Discuss:

(00:08) Mental Health Epidemic and Root Causes

(16:00) Metabolic Health in Mental Wellness

(33:38) Metabolic Health and Neurodevelopmental Disorders

(44:46) Holistic Approach to Mental Health

(59:26) Lifestyle and Metabolic Health Strategies

(01:13:16) Personal Stories of Dietary Transformation

(01:24:03) The Power of Metabolic Health

Thank You to Our Sponsors:

• TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/

• IFit: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/

• Nexthealth: NextHealth: Your destination for cutting-edge health optimization—from IV therapy to hormone balancing. Explore at https://www.next-health.com/

• Vitaboom: Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram: https://www.instagram.com/darshanshahmd/

Learn more about Dr. Chris Palmer:

Website:  https://www.chrispalmermd.com/ Instagram: https://www.instagram.com/chrispalmermd