In this mind-expanding conversation, psychiatrist and author Daniel Lieberman unpacks the role of dopamine — the brain's molecule of motivation — and how it shapes nearly every aspect of our lives, from love and ambition to addiction and impulsive behavior. Drawing from his bestselling book *The Molecule of More*, Lieberman explains why we’re wired to crave what's out of reach and why that craving often leads to restlessness, dissatisfaction, or destructive decisions. He contrasts dopamine’s future-focused drive with the chemistry of the present moment, exploring how we mistake infatuation for love, sabotage long-term happiness, and continually chase “more” even when we have enough. Packed with science, stories, and sobering insights, this episode offers a framework for understanding your own behavior and building a more balanced relationship with desire itself.

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In this powerful third appearance, bestselling author and decision strategist Annie Duke dismantles the myth that grit is always good — and makes the case for why strategic quitting is essential for success. Drawing from cognitive science, personal experience, and examples like Muhammad Ali, Dave Chappelle, and Stuart Butterfield (Slack), Duke illustrates how our obsession with persistence blinds us to opportunity costs, sunk cost fallacies, and identity traps.From failed startups to toxic jobs to long-dead relationships, this conversation explores why “quitting on time will feel like quitting too early”, and how tools like turnaround times and kill criteria can save your future. Annie also shares insights into why optimism can distort expected value, how founders sabotage themselves clinging to identity, and what Sears, a bankrupt retailer, can teach us about letting go.This episode is a reality check for dreamers, and a blueprint for making smarter, faster, braver decisions.

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Psychologist Anders Ericsson, the originator of the concept of deliberate practice, shares the foundational principles behind how experts are made—not born. Drawing on decades of empirical research, he explains how world-class performance emerges through structured effort, targeted feedback, and the development of mental models over time.Ericsson challenges myths around innate talent and demystifies the so-called 10,000-hour rule, emphasizing that quality and focus matter far more than raw repetition. He illustrates how deliberate practice applies not just to musicians and athletes, but to writers, interviewers, and anyone aiming for sustained high performance. He also explores the role of teachers, cognitive strain, and how to design practice that actually drives results.This conversation is a masterclass in what it really takes to achieve elite-level skill in any field.

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In this episode, Salim Ismail — founding executive director of Singularity University and author of *Exponential Organizations* — maps out what it takes to adapt, lead, and build in a world defined by accelerating change.He unpacks the frameworks behind exponential growth, the future of learning, and the architecture of modern organizations. But this isn’t just about scale — it’s about the inner transformation required to lead in chaotic environments. Salim discusses his own evolution, the importance of metaphysical inquiry, and how tools like NLP, flow-state hacking, and deliberate mindset engineering form the new foundation of personal and collective growth.Whether you're running a company, launching a project, or looking to expand your own operating system — this is an episode about thinking big, building differently, and staying grounded.

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Dennis Xu, co-founder of Mem, unpacks the future of personal knowledge and how it’s being reshaped by networked thinking, cognitive design, and human-centered AI. Drawing on his Stanford background, founder journey, and product philosophy, Dennis challenges the folder-based paradigms of information management — replacing them with malleable, graph-based systems that mirror how the human brain actually works. The conversation spans topics like information retrieval, product-market fit, second brains, deep work, and the difference between tourists and true builders in Silicon Valley. More than an app, Mem is portrayed as a thinking infrastructure for the modern knowledge worker. Together, Dennis and Srini explore how radical agency, creative autonomy, and better tools converge to help people manage complexity — without managing their software.

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Cognitive scientist Gloria Mark explains why modern knowledge work sabotages attention — and how to fight back. Drawing from her decades of research, she breaks down internal vs. external distraction, meta-awareness, cognitive rhythms, and the misunderstood nature of flow states. This episode delivers practical insights for reclaiming agency over your focus in a digital world designed to fragment it.

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Sonkhe Ahrens shares how traditional approaches to knowledge — highlighting, tagging, collecting — fail to support actual thinking. Drawing from Niklas Luhmann’s Zettelkasten method, Ahrens explains why insight isn’t something you plan for, but something you engineer into existence by connecting information deliberately over time. The conversation explores permanent notes, structured workflows, the failure of linear planning, and why writing is thinking — not a result of thinking. With over a thousand interviews as source material, Srini reflects on how note-taking became a creativity engine, not a storage problem. Together, they reveal a system where intellectual productivity compounds — and why the ability to retrieve insight is more powerful than hoarding information.

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Testing the upload functionality with markers.

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Kevin Surace breaks down how AI is reshaping the future of work — not by eliminating jobs, but by replacing repetitive tasks and redefining what humans are actually needed for. He explains why productivity, not headcount, will determine company growth in a labor-constrained world. Drawing from decades of applied AI experience, Surace outlines the evolution of tools like spreadsheets and calculators as previews of what’s coming next. The conversation dives into the need for adaptability, the reality of macro trends like demographic shifts, and how knowledge workers must rethink how they engage with technology. This is a blueprint for staying relevant in a world where task-based work is being automated — and insight, not repetition, defines value.

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Join us for a compelling conversation with Paul Millerd, author of The Pathless Path. In this episode, Paul shares his insights on finding yourself in the wrong life and the real work of figuring out how to live. Discover his journey through experiments, travels, and lessons learned, as he pieces together a set of principles to guide him from unfulfilled to the good life.

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