After the journey, the Spauldings established their mission in Lapwai, in what is now North Idaho. Eliza was well liked and respected by the Nez Perce. Henry, however, was not well liked, even resorting to whipping those who didn't obey. The Whitmans established their mission near present day Walla Walla. Narcissa did not like the always present Cayuse in her home. The influx of immigrants brought disease that nearly wiped out the Cayuse tribe. They ambushed the Whitmans killing them and eleven others.

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