This episode dives deep into how we treat advanced prostate cancer by targeting testosterone, specifically comparing surgical removal of the testicles (orchiectomy) with medical hormone therapy. You'll discover how these approaches stack up in terms of effectiveness for different patients, especially those with more challenging prognoses. We also explore the wide range of side effects patients face when testosterone levels drop, from impacts on sexual function and bone health to everyday challenges like fatigue and mood changes. Plus, we talk about the latest ways doctors and patients are managing these side effects to improve quality of life. It's a comprehensive look at how these crucial treatments affect a man's body and life.