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In Part 1 of this two-part series, Dr. Melissa Seibert sits down with Professor Bart Van Meerbeek, one of the most influential figures in adhesive dentistry worldwide. From dentin permeability to hybrid layer degradation, Professor Van Meerbeek's research has fundamentally shaped how clinicians understand the biological and mechanical realities of bonding. This conversation moves beyond product marketing and into the core science: what we truly know, what remains uncertain, and why durability in adhesion continues to require deliberate clinical judgment.

Together, they unpack the "adhesion degradation paradox," the hydrophilicity trade-off inherent in universal systems, and the persistent performance gap between simplified one-step adhesives and multi-step gold standards. The discussion explores film thickness, hydrophobic layering, stress distribution, and the biomechanical role of flowable composites as stress-relieving buffers. They also examine why 10-MDP concentration matters, why not all universal adhesives perform equivalently, and how bonding strategy should be tailored to substrate conditions—from young permeable dentin to sclerotic or amalgam-affected substrates.

This is not a discussion about shortcuts. It is a rigorous, clinically grounded examination of what evidence-based adhesive dentistry actually demands. If you are striving to practice with greater clarity, confidence, and scientific defensibility, this episode will recalibrate how you think about bonding protocols in everyday practice. Part 2 will continue the conversation, moving deeper into contamination management, clinical troubleshooting, and long-term durability.