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News topic du jour:

Pre-pandemic cognitive function and COVID-19 vaccine hesitancy: cohort study

"Vaccination is central to controlling the present pandemic, with success reliant on a sufficiently high uptake to achieve herd immunity (Omer et al., 2020).

1. CBD and testosterone [35:01] Jonathan says:

Hello

I am a 42 year old male, to the best of my knowledge, in good health. I strength train 4 times a week and am looking to keep my testosterone levels optimal. I have no reason to believe my testosterone levels are not good, but am cautious about taking supplements that have a known negative impacts on testosterone. I am hearing a lot of positive claims for CBD, and believe that you’ve talked about personally using it. Two that are most prominent is: 1. to reduce inflammation and 2. To reduce anxiety. Do you know what the effects of CBD on testosterone? How does this differ from THC? Thanks!

Jonathan

https://gaiaguru.co.uk/does-cbd-affect-hormones/#:~:text=CBD%20has%20been%20suggested%20to,break%20testosterone%20down%20(4).

"CBD has been suggested to reduce testosterone production by inhibiting the enzyme 17α‐hydroxylase, which makes Testosterone in leydig cells of the testes (4).

However, CBD also inhibits specific cytochrome p450 enzymes in the liver which break testosterone down (4)."

2. Omega 6:3 Ratio When Lowering Saturated Fat [38:19] Nathan says: Hi Robb,

First discovered your work in 2009 when podcast episodes were still single digits. My lungs had collapsed 14+ times, I had 3 lung surgeries, and long story short: I put a super rare autoimmune disease into remission thanks to you! In an effort to make this message easier to process, I've tried to ask the question first, then included context below if it's helpful.

QUESTION: Dr. Cromwell recommended that I try lowering saturated fats to less than 15% of total calories, keep total fat around 60%, retest in a couple months, then chat with him again. Seems like a good next step. I've been mostly eating low-carb paleo + full fat grass fed dairy (keto at times, for mental performance) so I've been getting lots of what I've considered high quality animal fats...but this recommendation has me scratching my head regarding where I should be getting my ~60% of calories from fat from. I'm planning to increase fatty fish like salmon in my diet, but I'm a bit worried about getting omega 6:3 ratios all out of whack if I cut out much of the grass fed beef, grassfed full fat dairy, wild game, etc I've been eating. Egads! Thoughts?

###

CONTEXT: After listening to your episode with Dr. William Cromwell, I ordered Cardiometabolic Risk Assessment and just got off a great call with him. Incredible person and amazing work he's doing. Anyway, everything looks good/great except for my cardiovascular risk, which is high (thanks to LDL-C at 174, non-HNL-C at 189, and ApoB at 136). I also have a family history of heart disease at a relatively young age, and though I'm only 34, I've been told that cardiac surgery in the future isn't much of an option on account of the fact that my lung surgeries essentially fused my lungs to my chest wall...so I basically need to just prevent cardiovascular disease in the first place. Given that I tested as highly insulin sensitive on his risk assessment, Cromwell said he'd expect me to do fine with up to 75g of carbs per day (currently doing 40-ish).

p.s., my sister is a fishing boat captain and runs the only all-female crew (badasses) up there. If you and the family ever make it up there, we could get you the family discount (free) to go out on the boat and catch hundreds of pounds of incredible fish to bring back! Great for little girls to see women doing such badass work as well! You've made a pretty indescribable impact on my and my family's health over the years, and it's hard to thank you enough!

3. CGM sensor and BJJ [45:40] Jared says: Hey Robb,

I'm making 2022 the "year of the data" and plan on spending time monitoring sleep, stress levels, etc with a wearable, testing ketones with finger pricks and tracking my blood glucose with a CGM (for at least a month). Any advice on where to place the sensor and how to secure it while rolling? I'm on the mats 4-6 times per week and I plan on using the Freestyle Libre 2 unless you have a better suggestion so ideally the sensor would stay stuck to me for 14 days. Thanks in advance for the insight and also for being a strong voice of nuanced reason during this covid shitshow.

Jared

 

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Transcript:

Can be found at:

https://robbwolf.com/2021/12/31/vaccine-hesitancy-cbd-and-testosterone-omega-36-while-reducing-sat-fat-thrr096