On this episode, I discuss the new medication vonoprazan and where it will likely be used in practice.

Vonoprazan is from a brand new class of medication called “PCAB”. I discuss this medication and its pharmacology in this podcast episode.

Drug interactions and cost are the two major downsides of this medication that will likely limit its use compared to the PPIs.

CYP3A4 inducers like rifampin, carbamazepine, and phenytoin should not be used with vonoprazan. They will reduce the effectiveness of vonoprazan.

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