While the U.S. was busy capturing Venezuelan President Nicolas Maduro, someone online was  busy placing bets on prediction markets on the ouster. And these well-timed bets may have netted a still-anonymous someone more than $400,000. Was this a case of kind-of-legal insider trading? Or is America going all-out on its efforts to make everything a casino?

We’re going to be talking to pediatrician Dr. Lauren Hughes about the major changes to the CDC vaccine schedule. We want your questions! Hit us up via email at [email protected] or leave us a voicemail at 646-582-0091. 

Guest: Alex Kirshner, Slate contributing writer

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Podcast production by Evan Campbell, and Patrick Fort.

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The Trump administration wants NASA to land astronauts on the moon by 2027. They also want them to do it with their budget slashed, a leadership carousel and competing views that Mars is more important. 

Guest: Joel Achenbach, freelance journalist and author of Moondoggle

If you want to support more of this reporting, in 2026 and beyond, consider signing up for Slate Plus. You’ll enjoy ad-free listening across the Slate network, early access to tickets for live events, and you’ll never hit the paywall on the site. Visit Slate.com/whatnextplus to sign up.

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Artificial intelligence boosters spent the year wedging the tech into our lives – whether we wanted it or not. But one new product brought A.I. from every app and website into the meatspace, forcing you to face it eye-to-eye.

Guest: Nitish Pahwa, staff writer at Slate covering business and technology

Want more What Next: TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/tbdplus to get access wherever you listen.

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With so much online content, it can be hard for a meme to stay in the collective consciousness for more than a few days. But one meme this year managed to capture seemingly everyone’s attention - and challenge the definition of a meme altogether. 

Guest: Kate Lindsay, host of Slate’s ICYMI podcast. 

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We’re on a mission to get 100 people to join Slate Plus before the new year—and we’re even offering a 50-percent-off deal to folks who join us right now. Visit Slate.com/whatnextplus and use the code TBD50 to get a year of Slate Plus for $59.

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All this week, What Next and What Next: TBD are re-airing some of our favorite conversations from throughout the year and checking back with the people in those conversations to see how things have – or haven’t – changed. This episode originally aired in September. 

We’ve been told that artificial intelligence can write, code, generate images—it can do everything…except feasibly turn a profit. But investing in A.I. has nevertheless become a pillar of the U.S. economy. Where is this leading us?

Guest: Ed Zitron, author of the newsletter Where’s Your Ed At and host of the podcast Better Offline.

If you want to support more of this reporting, in 2026 and beyond, consider signing up for Slate Plus. You’ll enjoy ad-free listening across the Slate network, early access to tickets for live events, and you’ll never hit the paywall on the site.

We’re on a mission to get 100 people to join Slate Plus before the new year—and we’re even offering a 50-percent-off deal to folks who join us right now. Visit Slate.com/whatnextplus and use the code WHATNEXT50 to get a year of Slate Plus for $59.

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All this week, What Next and What Next: TBD are re-airing some of our favorite conversations from throughout the year and checking back with the people in those conversations to see how things have – or haven’t – changed. This episode originally aired in March.

Memecoins are a niche type of cryptocurrency with no intrinsic value. But they remain a popular form of crypto, as seen earlier this year with President Trump’s own memecoin. And if it worked for him, then why not our little podcast? 

Guests: 

Azeem Khan, advisor to UNICEF’s crypto fund and cocreator of the blockchain Morph.

Nitish Pahwa, Slate staff writer covering business and tech.

If you want to support more of this reporting, in 2026 and beyond, consider signing up for Slate Plus. You’ll enjoy ad-free listening across the Slate network, early access to tickets for live events, and you’ll never hit the paywall on the site.

 
We’re on a mission to get 100 people to join Slate Plus before the new year—and we’re even offering a 50-percent-off deal to folks who join us right now. Visit Slate.com/whatnextplus and use the code WHATNEXT50 to get a year of Slate Plus for $59.

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While the A.I. boom has created a data center boom, rich guys are turning their computing dreams to the skies. With its impending IPO, SpaceX stands to lead the extraterrestrial data center boom. Will it work out for Elon and company? 

Guest: Eric Berger, space reporter at Ars Technica

Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.

Podcast production by Evan Campbell, and Patrick Fort.

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Whole Foods based its brand on a certain standard of quality—but there are some things that shoppers nevertheless want. Amazon believes it has found a way to keep the shelves looking like Whole Foods, while getting you the Tide PODS  and Cheez-Its you deeply desire.

Guest: Peyton Bigora, staff reporter for Grocery Dive

Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.

Podcast production by Evan Campbell, and Patrick Fort.

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The good news is voters are more persuaded by factual claims than emotional appeals or appeals to fear. But the bad news is that A.I. chatbots, trying to convince you, will keep making factual claims long after it runs out of actual facts.

Guest: David Rand, professor of information science, marketing and psychology at Cornell University

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Donald Trump—or at least the tech guys who have his ear—is ready to clear the regulatory runway for A.I. but other Republicans aren’t too sure. Can he bring them around? Or will the bubble burst first?

Guest: Gerrit De Vynck, tech reporter for the Washington Post.

Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.

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