Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

What We Learned About the Brain in 2025 | Stress, Perception & Healing


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What if the qualities you’ve been taught to override are actually the ones keeping you well?


To round of 2025, I’m joined by world-leading thinkers including Simon Sinek, Dr. Rick Doblin, Robin Sharma, Professor Nicolau, and Dr. Sarah McKay to explore what truly shapes our wellbeing when the noise fades and the signal becomes clearer.


This episode weaves together some of the most powerful moments from conversations across the year. From introversion and energy boundaries, to trauma, inflammation, digital overload, recovery, and the stories we tell about our bodies, this is a reminder that health is not about optimisation, it’s about understanding cost, context, and care.


Across neuroscience, psychology, leadership, and physiology, a shared truth emerges. Our systems are intelligent. But they are not limitless. And when we listen earlier, we protect ourselves from paying a higher price later.


Here’s What We Dive Into:


- How introversion can be a strength in leadership, communication, and meaningful connection.


- Why wellbeing is less about right versus wrong, and more about understanding personal cost.


- How MDMA


-assisted therapy works in the brain to support healing from PTSD — and why context matters more than the compound.


- What recovery actually looks like in a world that rewards constant output.


- Why strategic rest and “going ghost” can unlock creativity, clarity, and long-term performance.


- How social media content — not just screen time — may drive inflammation and immune stress.


- Why chronic stress and burnout can permanently shift our inflammatory baseline.


- How cultural narratives shape emotional experiences, including PMS and mood changes.


Love,

Sarah Ann 💛


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This episode is sponsored by:


NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at nowatch.com


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Let’s be friends!

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Sign up to Sarah’s Compassionate Cure newsletter:Science Simplified, Health Humanised.Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.https://sarahmacklin.substack.com/


👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://open.substack.com/pub/sarahmacklin/p/download-your-free-5-recipes-to-relieve


👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week. https://sarahmacklin.substack.com/



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If You Enjoyed This Episode, You Might Also Like:


Simon Sinek on Leadership, Energy, and Meaningful WorkSimon Sinek: The ADHD Superpower - Why It’s My Greatest Advantage


Dr. Rick Doblin on Trauma, Healing, and Psychedelic ScienceHow Psychedelics Change the Brain: MDMA, Psilocybin, Benefits & Risks | Dr. Rick Doblin


Dr. Sarah McKay on Women’s Brains, Hormones, and Emotional HealthWomen's Brain Health: What Science REALLY Says About Hormones, PMS & Menopause | Dr Sarah McKay


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Highlights:


00:00:00 Intro

00:02:00 My ADHD Superpower - Why it’s my greatest advantage | Simon Sinek

00:11:23 How Psychedelics Change the Brain: MDMA, Psilocybin, Benefits and Risks | Dr Rick Doblin

00:18:51 Stop Chasing Money: 8 Hidden Forms of Wealth You Need Now | Robin Sharma

00:24:05 The Brain Immune Expert: Alert! Social Media is Reprogramming Your Immune System | Dr Dan Nicolau Jr

00:39:24 Women’s Brain Health: What Science Really Says About Hormones, PMS, and Menopause | Dr Sarah McKay


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Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, NutritionBy Sarah Ann Macklin

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