Homeland Security Secretary Kristi Noem is out, after a damaging appearance before the Senate, as Donald Trump names Markwayne Mullin to replace her. Will the DHS personnel change also affect ICE policy? Plus, does the U.S. have enough air-defense interceptors to maintain deterrence while finishing the job in Iran?

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 Paul Gigot interviews Hudson Institute Middle East expert Michael Doran, who says the military campaign is going well for the U.S. and Israel. But the aftermath is far from certain as Donald Trump aims for 'regime transformation' rather than a revolution.

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Federal law prohibits users of illegal drugs from owning guns, but does this violate the Second Amendment? The Justices debate that question, with a focus on how the Founders handled "drunkards." Plus, James Talarico wins the Democratic Senate nod in Texas, as John Cornyn and Ken Paxton head to a GOP runoff.

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Democrats hope surging voter enthusiasm will turn Texas blue this fall, but candidate quality matters. On the Republican side, Sen. John Cornyn faces a stiff challenge from Attorney General Ken Paxton, who is loud but has liabilities. Democrats also have contrast of personalities in Jasmine Crockett vs. James Talarico.

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A joint operation by the United States and Israel on Iran leads to the assassination of Ayatollah Ali Khamenei, with Donald Trump promising more strikes over the next four to five weeks. Will this lead to regime change in the region, and what will it take for the President to declare a strategic victory?

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Federal workers with TSA airport security and the Coast Guard are receiving partial paychecks, after Democrats again refuse to fund the Department of Homeland Security without major reforms to ICE. Plus tech firms prepare to visit the White House, as Donald Trump tells them to generate their own electricity.

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Steve Witkoff and Jared Kushner begin a round of indirect talks with Iranian officials over the country’s nuclear program and ballistic missiles. President Trump says he wants a diplomatic solution, but has he effectively made his case to the American people if he decides to launch a possible strike on Iran?

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Donald Trump declares victory on the economy, frames the Democratic Party as extreme, and offers praise for JD Vance and Marco Rubio, in one of the longest State of the Union speeches in recent times. But what's the agenda that Republicans can carry into the midterms? Plus, Virginia Gov. Abigail Spanberger delivers a Democratic response that starts with affordability, yet her party’s nominees in November might be moving further left.

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American officials say they believe China held a nuclear test in 2020, and President Trump reserves the right to do the same, as the New Start arms-control treaty with Russia hits its expiration date this month. Plus, the Food and Drug Administration summarily rejects a flu vaccine from Moderna, before changing course.

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Now that the Supreme Court has struck down Donald Trump's "emergency" tariffs, will the government refund the billions of dollars it unlawfully collected? And as Trump turns to other tariff authorities, how much will he be limited by the guardrails written into those laws? The Cato Institute’s trade expert Scott Lincicome discusses.

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