Dr. John Sia, Infectious Diseases Fellow at the Morsani College of Medicine, shares a grand rounds presentation on the national One Health Framework for addressing zoonotic diseases in the U.S. Dr. Sia introduces a clinical case involving a patient exposed to a zoonotic infection. Next, he covers different zoonotic pathogens and their vectors and focuses on Bartonella, Bacillus anthracis, and Brucella. Next, he describes how the One Health initiative helps teams of medical clinicians, scientists, and veterinarians to address disease threats in a collaborative fashion. After brief descriptions of two more cases, Dr. Sia closes with further examples of how the One Health Initiative is beneficial in combating antimicrobial resistance and connecting human, animal, and environmental health.