One of the most popular dietary supplement ingredients on the planet — especially in terms of metabolic health — is berberine. Today we discuss a new ingredient that actually makes berberine obsolete.

Berberine is a powerful plant alkaloid that improves the body’s insulin response, with large amounts of scientific research showing significant improvements to insulin sensitivity, fasting glucose levels, HbA1c reduction, nutrient partitioning, and far more. It’s even outperformed pharmaceutical drugs.

We’ve covered berberine in detail in the article linked above, ultimately finding that while it’s the most impressive ingredient in any blood sugar supplement or glucose disposal agent, it has drawbacks, which include high doses required and GI distress. Both of those problems are solved with one of its derivatives that we specifically cover in this article: dihydroberberine.

Think berberine is good? Take a look at dihydroberberine

Research suggests that dihydroberberine is up to six times better than standard berberine, bringing incredible effects at lower doses — and fewer side effects.

In this article, we assume you have knowledge of berberine’s effects (if not, you can see our berberine article linked above), but jump directly into discussion of this dihydro form. It’s sold as GlucoVantage from NNB Nutrition, one of the supplement industry’s most promising novel ingredient developers.

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Burn fat, not sugar

The world of diet and fat loss can be overwhelming, but one quick rule to live by is this: when you’re burning sugar, you’re not burning fat. In fact, we’ve known for decades that when either blood glucose levels or insulin levels are elevated, fat oxidation significantly slows. If these levels remain elevated for too long, we introduce insulin resistance and hyperinsulinemia, which brings with it a myriad of diseases.

This isn’t to say that we’re against foods like carbohydrates that raise blood sugar (and insulin) levels, because we’re not. Instead, it means that we need to get our carbs to where we want them (muscle tissue!) and get back to a fat-metabolizing state as soon as possible. Berberine, and to a greater extent, dihydroberberine, make that happen better and faster.

We of course still recommend a healthy diet low in refined carbs and void of industrial processed seed oils high in omega-6. But with the above supplemental strategy (which is highlighted in our main berberine article), we can remain more insulin-sensitive, and less likely to be as toxic with sugar and insulin in our blood stream wreaking havoc.

With that goal in mind, we can talk about a new, more-efficient way to achieve it, all while avoiding the massive doses (1.5 grams per day!) and gastrointestinal distress that can be brought by standard, low-bioavailability berberine:

What is dihydroberberine?

Dihydroberberine (DHB) is one of the 17 metabolites of berberine, and a major part of the greater berberine life cycle as the body metabolizes it. Structurally, it’s a hydrogenated metabolite of berberine, which itself has markedly better oral bioavailability than berberine itself.

The berberine end-around play

The concern, at this point, is that if you take the more-bioavailable dihydroberberine, do you miss out on the 16 other metabolites that may have been providing some of berberine’s benefits? The answer is no, because of the way be…

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