Dr. Jeff Thompson, CEO Emeritus with the Gundersen Health System in La Crosse, WI, and Catalysis Board member, discussed the importance of culture and principles in effective and sustainable organizational change. As well as the steps necessary to operationalizing a principle-based approach to culture change and continuous improvement. A principle-based approach has been valuable to many healthcare organizations as they navigate and respond to the changing environment that the COVID-19 pandemic presents.