What right ventricular end-systolic volume should guide timing of pulmonary valve replacement in tetralogy of Fallot? At what pulmonary vascular resistance can closure be pursued for an atrial septal defect in patients with pulmonary hypertension? How often should Fontan patients receive liver imaging and alpha-fetoprotein screening? Should patients with Eisenmenger syndrome be routinely anticoagulated? What is the maternal mortality risk for pregnancy in Eisenmenger syndrome? Should most pregnant patients with adult congenital heart disease undergo cesarean delivery? Should cyanotic ACHD patients undergo prophylactic phlebotomy? Can ACHD patients participate in competitive sports? Watch for answers to these key questions in this "deep dive" of the 2025 ACC/AHA Guideline for the Management of Adults with Congenital Heart Disease.Difficulty Level: Advanced

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