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What if psilocybin wasn’t just a mental health breakthrough — but a longevity intervention?
In this powerful, science-driven conversation, Dr. Louise Hecker shares groundbreaking research exploring how psilocybin’s active metabolite, psilocin, may influence the fundamental biology of aging.
We explore:
• How psilocybin impacts cellular senescence, one of the key drivers of aging
• The surprising effects on oxidative stress and antioxidant pathways
• What happened to telomere length in aging cell models
• Why serotonin (5-HT) receptors exist throughout the body — not just the brain
• The dramatic survival results in aged mice given monthly high-dose psilocybin
• Why psychedelic research was stalled for decades — and what’s changing now
• The potential role of psilocybin as a future geroprotective agent
This episode moves beyond hype and into mechanism — exploring how psychedelics may influence healthspan at the cellular and systemic level.
A fascinating look at how a once-misunderstood compound could reshape preventative medicine and aging science.
By Claudia von Boeselager4.9
2828 ratings
What if psilocybin wasn’t just a mental health breakthrough — but a longevity intervention?
In this powerful, science-driven conversation, Dr. Louise Hecker shares groundbreaking research exploring how psilocybin’s active metabolite, psilocin, may influence the fundamental biology of aging.
We explore:
• How psilocybin impacts cellular senescence, one of the key drivers of aging
• The surprising effects on oxidative stress and antioxidant pathways
• What happened to telomere length in aging cell models
• Why serotonin (5-HT) receptors exist throughout the body — not just the brain
• The dramatic survival results in aged mice given monthly high-dose psilocybin
• Why psychedelic research was stalled for decades — and what’s changing now
• The potential role of psilocybin as a future geroprotective agent
This episode moves beyond hype and into mechanism — exploring how psychedelics may influence healthspan at the cellular and systemic level.
A fascinating look at how a once-misunderstood compound could reshape preventative medicine and aging science.

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