The Longevity & Lifestyle Podcast

#240 Dr. Louise Hecker — Can Psilocybin Slow Aging? The First Study on Telomeres, Cellular Longevity & Systemic Anti-Aging


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What if psilocybin wasn’t just a mental health breakthrough — but a longevity intervention?


In this powerful, science-driven conversation, Dr. Louise Hecker shares groundbreaking research exploring how psilocybin’s active metabolite, psilocin, may influence the fundamental biology of aging.


We explore:


• How psilocybin impacts cellular senescence, one of the key drivers of aging

• The surprising effects on oxidative stress and antioxidant pathways

• What happened to telomere length in aging cell models

• Why serotonin (5-HT) receptors exist throughout the body — not just the brain

• The dramatic survival results in aged mice given monthly high-dose psilocybin

• Why psychedelic research was stalled for decades — and what’s changing now

• The potential role of psilocybin as a future geroprotective agent


This episode moves beyond hype and into mechanism — exploring how psychedelics may influence healthspan at the cellular and systemic level.


A fascinating look at how a once-misunderstood compound could reshape preventative medicine and aging science.



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