The Longevity & Lifestyle Podcast

#249 Dr. Momchilo Vuyisich — How Your Microbiome Controls Immunity, Chronic Disease & Longevity


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What if your microbiome is influencing far more than digestion - from your brain and immune system to aging, energy and chronic disease risk?

In this fascinating episode, Dr. Momchil “Momo” Vuyisich joins Claudia to unpack the science of the microbiome, microbial function and personalized nutrition.

We explore:

• Why Your Gut Microbiome Shapes Human Health
• The Difference Between Microbes and Microbial Function
• How Gut Bacteria Influence Brain Health and Cognition
• Why Antibiotic Overuse May Increase Chronic Disease Risk
• The Role of Fermented Foods and Probiotics
• Why Personalized Nutrition Is the Future of Healthcare
• The Importance of Keystone Species Like Akkermansia
• How Food Preservatives and Modern Diets Affect the Gut
• Why Testing and Data Create Actionable Health Insights
• The Future of Microbiome Science and Precision Health

This conversation is a powerful reminder that longevity starts with understanding the invisible ecosystem living inside us.


Timestamps
00:00 - Why chronic stress may be destroying your body
00:38 - Dr. Momchilo Vuyisich’s background and work at Viome
01:33 - Why humans are an ecosystem, not just an individual
03:58 - Why fiber is essential for feeding the microbiome
04:52 - How the microbiome is shaped at birth
06:31 - Why asthma, food allergies, and IBD may be rising
08:13 - How mothers can support a healthier microbiome before pregnancy
09:40 - The hidden long-term cost of antibiotics
11:06 - How preservatives and non-organic meat may harm the microbiome
12:22 - How to rewild your microbiome after disruption
16:46 - Why some keystone strains are so hard to restore
18:19 - Microbial function vs. microbial strains
20:49 - How microbial metabolites affect the brain and body
24:25 - Why personalized nutrition may matter more than generic healthy eating
27:20 - The four pillars of health: food, exercise, Zen, and sleep
29:58 - Why there is no single optimal diet for everyone
32:34 - Minimum effective exercise for longevity
34:21 - Why stress management is non-negotiable
37:48 - Why sleep sets up your entire next day
39:33 - Are naps helpful or harmful?
40:22 - The microbiome and neurodivergence
43:07 - Can chronic disease become preventable?
44:31 - Preventive maintenance for the human body
46:34 - How the microbiome may influence immune memory
48:13 - What Dr. Vuyisich is building at Viome now
51:15 - Where to follow Dr. Vuyisich and learn more

Subscribe to Longevity & Lifestyle for science-backed insights on longevity, health optimization, brain health, metabolic health, women’s health, and performance.

#microbiome #guthealth #longevity #healthoptimization #immunity #brainhealth #metabolichealth #personalizednutrition #biohacking #healthyaging

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The Longevity & Lifestyle PodcastBy Claudia von Boeselager

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