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In this episode Dr. Murali Premkumar (Texas Children’s) presents an Explore/CHNC analysis of stricture formation after surgical NEC using 2010–2024 CHND data (2,411 surgical NEC infants). Overall CHNC stricture incidence ≈31% with marked inter-center variability (adjusted center rates ~24–38%). Multivariable analysis identified lower gestational age and stoma/laparotomy as associated with higher stricture risk, while initial peritoneal drainage associated with lower risk; Hispanic ethnicity showed lower unadjusted risk. A predictive model yielded AUC 0.67, highlighting missing variables (antibiotic duration, feeding practices). Practical implications: use these benchmarks to counsel families, generate hypotheses, and target QI by studying low-risk centers.

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