In episode 529 of Sigma Nutrition Radio, we discuss all things related to cholesterol, atherosclerosis, heart disease, and dietary fat. The discussion extensively covers the impact of LDL cholesterol and ApoB on atherosclerotic plaque progression, cardiovascular events, and the benefits of early LDL lowering interventions, particularly through the use of PCSK9 inhibitors alongside statins.

We address misconceptions prevalent in the low-carb and carnivore communities, dissect claims regarding saturated fats, and elucidate why atherosclerosis predominantly affects arteries and not veins. The episode sheds light on the nuanced mechanisms of cholesterol metabolism, the significance of different lipid particles, and the limited dietary impact on LP(a) levels.

Comprehensive evidence-based insights and practical recommendations for dietary patterns and cardiovascular health interventions are provided, offering clarity on these complex topics.

Note: This discussion is hosted by Simon Hill, and originally appeared as an episode of The Proof podcast.

Links:

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• Episode with Professor Chris Packard

Timestamps:

• 07:19 Understanding Cholesterol and Lipoproteins
• 14:35 The Role of ApoB in Cardiovascular Risk
• 25:10 Atherogenic Lipoproteins and Their Impact
• 37:42 Causal Pathways and Biomarkers in Heart Disease
• 47:02 Understanding Residual Risk and Triglycerides
• 49:46 Paul Saladino's Claims on LDL and Metabolic Health
• 01:03:01 Addressing Concerns About Lowering Cholesterol
• 01:16:16 The Importance of Early Intervention in Cholesterol Management
• 01:23:36 The Future of Cholesterol Management and Gene Editing
• 01:28:24 Atherosclerosis in Arteries vs. Veins
• 01:36:08 Dietary Interventions to Lower ApoB Levels
• 01:47:55 Modifying Keto Diet for Better Health Outcomes
• 01:56:33 Plant-Based Diets and Fat Consumption
• 02:05:10 Understanding Lp(a) and Its Impact on Health

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