Our next AAOS 2024 Annual Meeting poster is titled The Statistical Fragility of Platelet-Rich Plasma in Lateral Epicondylitis: A Systematic Review and Simulated Fragility Analysis of Randomized Controlled Trials. Our podcast tries to stay far away from statistical analysis and methodology breakdown; however, this poster draws attention to an important issue. Often in orthopedics we try to use statistically significant findings –defined as those with a p value of less than .05 – from Level I randomized controlled trials to guide our clinical decision making. This poster suggests that is not all we should be looking at, particularly as it pertains to the use of PRP for lateral epicondylitis.