Please note that this episode contains discussions about suicidal ideation, which some listeners may find distressing. If you or someone you know is affected by these kinds of issues, we encourage you to seek support from professional services. 

Heather Cruickshank was pursuing a lifelong dream to become a medical doctor when bipolar disorder, a complex mental health condition, stopped her in her tracks and forced her to rethink her career. A chance encounter with QBI Associate Professor Susannah Tye, internationally renowned for her research into the biological mechanisms behind mood disorders, encouraged Heather to use her lived experience to pave the way for more effective treatments for bipolar disorder.    

 In this compelling conversation, Sue and Heather explore:

 ·       The link between mental and physical health 

·       What it’s like to have bipolar disorder 

·       Why studying the biology of mood disorders matters 

·       The role of melatonin, oxidative stress and dopamine

·       How lived experience can help shape research

While countless supplements and products promise to reverse aging without scientific proof, the real secret to defying age may be found in the study of epigenetics. This field of study explores how our behaviours and environment can lead to changes that influence how our genes function. 

Dr Anne Hahn from the Zuryn laboratory has recently discovered a mechanism in the DNA of genes that regulates how disease-causing mutations are inherited. The findings offer a promising therapeutic avenue to stop the onset of heritable and age-related diseases. 

In this informative interview Dr Hahn explains:

Why the old belief that DNA mutations inevitably lead to disease might not be true

The important part mitochondria play in cell ageing

The lifestyle factors the can influence our genetic make-up

Why epigenetic modification is important in age-related diseases

Related Resources 

Cell protein discovery points to healthier ageing

Dr Matt Kenna is fascinated by the science of memory. As a researcher at UQ’s Queensland Brain Institute, Matt is tasked with challenging prominent theories centred around one of the biggest unknowns in the world of neuroscience. Memory is fundamental to our identity, shaping who we are. As a member of the Sah lab, Matt studies synaptic plasticity to explore how memories are formed, retrieved, and influence behavior.

In this engaging conversation, Matt discusses:

• How memory is defined
• Where memories are stored in the brain
• The importance of sleep in consolidating memory
• Why some memories are more important than others
• How we can delay cognitive decline and improve memory in old age

Related papers and resources

Interpreting memory: Research and Innovation Week 2024

Podcast: Train your brain

UQ Research reveals exercise brain boost can last for years

UQ Research reveals new brain networks critical to memory formation

Professor John McGrath, a distinguished clinician and researcher at UQ's Queensland Brain Institute, is at the forefront of global mental health research. Growing up in Brisbane, John initially pursued a career as a psychiatrist before transitioning to groundbreaking research aimed at unraveling the complexities of mental health disorders. Co-leading a major international study in collaboration with The University of Queensland and Harvard Medical School, John’s research revealed that one in two people will develop a mental health disorder by the age of 75. This pivotal study sheds light on crucial questions about mental health.

In this fascinating conversation, Professor McGrath discusses:

• The recent study findings showing how half of us will develop a mental health disorder by age 75.
• What epidemiology means, and why its useful in understanding mental health.
• The value of discovery science.
• The beauty of collaboration to reach a common goal.
• Whether mental health disorders could be prevented in the future.

Mr Mehershad Wadia has written numerous scripts for short comedies screened at international film festivals like Mumbai and San Francisco, joined the writing team for the third season of The Office India and published a children’s book. Matching his passion for entertainment is Mehershad’s commitment to brain research. He is adamant there is no reason to choose between the two. At UQ’s Queensland Brain Institute, Mehershad works in the Hilliard lab, studying the nervous system of c.elegans.  

In this insightful conversation, Mehershad explains:  

• How the right experimental conditions led to a stand-up comedy career 
• What studying worm brains can teach us about the human brain 
• The parallels between comedy and science 
• Why he became a writer for The Office during the pandemic 
• How skills in the arts and science are helpful in any career.  

Professor Gail Robinson has developed a new diagnostic tool to assess cognitive function in post-stroke patients called The Brief Executive Language Screening Test (BELS). This brief 20-minute test, can predict how much a stroke patient will recover to function independently in their first year.

In this informative podcast, Professor Robinson discusses:

• Stroke symptoms and causes
• Warning signs of a stroke
• The window that the BELS test can be taken to best inform recovery
• The typical clinical pathway of a stroke patient
• Lifestyle factors that can cause a stroke

We know exercise is beneficial for our body and mind. Research has shown that neurogenesis – the production of neurons in the brain – continues throughout our lives and is key to improving cognition.

 At the Queensland Brain Institute, Dr Daniel Blackmore, has been captivated by this process of neurogenesis. Alongside colleagues from The University of Queensland, he completed a comprehensive study, investigating the potential of exercise in mitigating the cognitive decline associated with diseases impacting learning and memory.

 In this fascinating conversation, Dr Blackmore discusses:

 What is happening in the brain at the onset of dementia?

How stem cells are important in producing new neurons?

What did you find out from the study?

What type of exercise leads to cognitive improvement?

Is there still more we can discover from this one study?

Dr Bonnie Searle is passionate about getting children to eat. In her past life as a paediatric dietitian for children with food aversions, she experienced first-hand the power of changing how we feed children. 

She is currently working on a special research project at the Queensland Brain Institute, called Mealtimes Matter, which suggests that there are some serious nutritional deficiencies in some childcare centres, particularly in disadvantaged areas, that is having a detrimental effect on child development. 

In this insightful conversation, Dr Searle discusses:

• Why nutrition is important for developing brains
• The quality of nutrition at childcare centres across Queensland
• Healthy lunchbox tips
• Tips for fussy eaters

What do Wally Lewis AM and Nic Berry have in common? Quite a lot, it turns out. Wally started playing rugby union before switching codes to rugby league, becoming a legend of the game. Nic kicked off in rugby league before his professional career in rugby union, first as a player and now as an international match official. Both have also experienced significant head knocks in rugby and, with the benefit of hindsight, are passionate supporters of QBI’s concussion research.

In this relaxed conversation, they share:  

• What they love about the game 
• Their experiences of concussion in professional sport 
• How the game has changed in the past decade 
• What’s been done to protect the players 
• Why more awareness and research are needed  

Related resources  

What is concussion?  

Concussion signs and symptoms  

About concussion research  

QBI concussion study (high school athletes)