This audio program discusses severe mood dysregulation and bipolar disorder in children; a longitudinal study of cortical development in children with varying degrees of hyperactivity; whether gray matter volume in adults being treated for alcohol dependence is related to the time until relapse; a schizophrenia study comparing mortality rates for ziprasidone and olanzapine; use of technology to obtain real-time assessments of symptoms and substance use in schizophrenia patients. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses a follow-up investigation of patients with major depression over intervals as long as 31 years to determine whether subclinical hypomanic symptoms at baseline were related to the later emergence of bipolar disorder; a 7-year study examining whether children who experience abuse, bullying, or accidents are more likely to develop psychotic symptoms; baseline number of glucocorticoid receptors as a possible biomarker of posttraumatic stress symptoms, tested in military personnel with and without high levels of PTSD symptoms after 6 months of deployment; a further examination of the association between suicide and high altitude that included the influence of gun ownership and rural location; and whether the relationship between paternal age and schizophrenia risk is the result of de novo mutations or later fatherhood for men with a predisposition to schizophrenia. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses deep brain stimulation for treatment of depression; personalized medicine for depression; national trends in outpatient psychotherapy; the relationship of childhood bullying to outcomes in young adulthood; and an intervention for parents of young children with behavioral inhibition to alter the risk of subsequent anxiety disorders. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses public perceptions of mental illness, research on the neural circuitry of postpartum depression, the genetics of autism, and psychotherapy for older adults with major depression and executive dysfunction. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses delirium in infants in critical care settings; a study of suicidal women with borderline personality disorder comparing subgroups with and without PTSD; subthreshold hypomania in major depressive disorder patients; effect of hypertension and body mass index on cognition in schizophrenia; and the relationship of antidepressant step therapy to overall medical utilization and spending. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses psychiatric manifestations of paraneoplastic disorders; prenatal and neonatal brain structure in children at high risk for schizophrenia; prediction of psychosis by negative and disorganized symptoms in adolescents and young adults; and how histamine-related genes influence the effects of food additives on children’s ADHD symptoms. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses two-phase psychotherapy for PTSD related to childhood abuse, rapid versus gradual discontinuation of antidepressants, augmentation of antidepressants with SAMe, and endogenous opioid function in borderline personality disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses the clinical case of a patient with both psychotic and obsessive-compulsive symptoms; the treatment of adolescent depression including 24-week outcomes of the TORDIA study; use of long-term fluoxetine versus lithium for relapse prevention in bipolar II disorder patients; the rationale and features of the Research Domain Criteria, a proposed framework for research on pathophysiology to inform future schemes for classification of mental disorders. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses the use of medications for three different types of alcohol dependence; a clinical trial of treatment for comorbid alcohol dependence and depression in which the combination of sertraline and naltrexone was compared with the individual drugs and placebo; a trial of risperidone for maintenance treatment of schizophrenia; recommendations for antipsychotic dosing based on international expert consensus; a 10-year prospective study that tracked remission and recovery from borderline personality disorder in a group of hospitalized patients; a review of the evidence for a dissociative subtype of posttraumatic stress disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses a long-term study examining how the depressive state affects the assessment of personality disorder; the pharmacogenetics of antidepressant response; the association between depression and incident diabetes; how brain activity of patients with generalized anxiety disorder reacts to emotional conflict; and the neuropsychiatric aspects of lupus in a patient case that also involved erotomania and the Geschwind syndrome. Articles can be viewed online at www.ajp.psychiatryonline.org.