Moderator: James P. Rathmell, M.D. Participants: Carmen Bozic, M.D. Articles Discussed: Suzetrigine, a Nonopioid NaV1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials Suzetrigine: First in a New Class of Nonopioid Analgesics for Acute Pain

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Moderator: James P. Rathmell, M.D. Participants: Rebecca L. Wu, M.D. and Max B. Kelz, M.D., Ph.D. Articles Discussed: TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males Alluring Potential to Accelerate Emergence and Ameliorate Opioid-induced Respiratory Depression without Antagonizing Analgesia: Danavorexton Enters the Anesthetic Landscape Transcript

Moderator: BobbieJean, M.D. Participants: Douglas Colquhoun, M.B., M.Sc., M.P.H. and Stephan R. Thilen Articles Discussed: Neuromuscular Blockade and Antagonism in Patients with Renal Impairment: A Multicenter Retrospective Cross Sectional Study On and Off Label Use of Sugammadex in Patients with Renal Impairment in the 6 ½ Years Following FDA Approval Transcript

Creator: James P. Rathmell, M.D., M.B.A.

June 2025, Volume 142, Issue 6

Overview of June issue original studies.

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Moderator: BobbieJean Sweitzer, M.D. Participants: Daqing Ma, Ph.D. and Kate Leslie, M.B.B.S., M.D. Articles Discussed: Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery: A Double-blind Randomized Controlled Trial B6 or Be Sick? Pyridoxine to Prevent Postoperative Nausea and Vomiting Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Alessandro Belletti, M.D., and Samuel N. Heyman, M.D. Articles Discussed: Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial Amino Acid Infusion for the Prevention of Acute Kidney Injury: Yet a Debatable Issue

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Moderator: James P. Rathmell, M.D. Participants: Christopher Connor, M.D., Ph.D. and Peter John Schuller, M.B.B.S., B.Sc. Articles Discussed: Developing an EEG-based model to predict awakening after cardiac arrest using partial processing with the BIS Engine Unlocking Prognostic Potential in the Postarrest Electroencephalogram

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Creator: James P. Rathmell, M.D., M.B.A.

May 2025, Volume 142, Issue 5

Overview of May issue original studies.

Creator: James P. Rathmell, M.D., M.B.A.

April 2025, Volume 142, Issue 4

Overview of April issue original studies.

Moderator: James P. Rathmell, M.D. Participants: Yuming Peng, M.D., Ph.D. and Philip Devereaux, M.D., Ph.D. Articles Discussed: Covert Perioperative Strokes in Older Patients Having Noncardiac Surgery (PRECISION): A Prospective Cohort Analysis Perioperative Covert Stroke: Acutely Asymptomatic but Not Benign Transcript