Executive Editor Michael Roy speaks with Lori A. Zoellner, Ph.D., about her research on how patient treatment preference affects outcomes in the treatment of posttraumatic stress disorder (PTSD).

In a doubly randomized preference trial, 200 patients with PTSD viewed standardized treatment rationales prior to randomization. Patients were first randomized to choice of treatment or no choice. Those assigned to no choice were then randomized to prolonged exposure or sertraline. Acute treatment was 10 weeks, with 24-month follow-up. Interviewer-rated PTSD symptom severity was the main outcome measure, and depression, anxiety, and functioning were assessed as additional outcomes.

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