Ben and David go on "This Week in Startups" with Jason Calacanis for a holiday special!  Discussion includes: - Talking TWIST and All-In this year with everything from politics to weight loss to private jets - Acquired's year and some of Ben and David's biggest insights from episodes - VC, valuations, and crypto investing mechanics - Use cases for crypto, and trying to get Jason (a skeptic) excited - Carveouts: our favorite books, podcasts, and TV shows from this year  Sponsors:Quartr

Ben and David on "This Week in Startups" Holiday Special

ACQ2 is Ben and David's conversations with expert founders and investors. Acquired the stories of great companies — and ACQ2 dives deeper into the lessons we can learn from them, often with the protagonists themselves.

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On our Novo Nordisk episode, we covered the business of Ozempic, the GLP-1 taking the world by storm. On this episode, we dive into the science of the molecule semaglutide (and its predecessor liraglutide) with the world expert on the topic, Lotte Bjerre Knudsen. Lotte is Novo Nordisk’s Chief Scientific Advisor, and led the research group back in the early 1990s that first invented the molecule. A few topics from our conversation:The science behind what is happening in the body that causes weight loss while on OzempicWhat it was like in the 1990s and 2000s believing in a drug for a problem that the rest of the industry (including her own company) had written offHow weight loss was actually a goal from the very start — not just a side effect of diabetes medication like you often read today! Sponsors:Quartr


The Scientific Journey Behind Ozempic (with Lotte Bjerre Knudsen, Novo Nordisk's Chief Scientific Advisor)

We’re joined by Imprint cofounder and Thrive General Partner Gaurav Ahuja to dive deeper into the modern payments ecosystem and Visa’s current place within it. Gaurav was one of our research sources for the Visa episode, and we wanted to bring his insights to you all too. We discuss whether Visa really should be worried about eroding interchange fees, the impact of realtime payments systems, opportunities for startups and whether the Visa / Mastercard duopoly could really be overthrown. Tune in and enjoy! 
Links:https://www.federalreserve.gov/paymentsystems/files/Avg_IF_by_PCN.pdf Sponsors:Quartr


Visa Follow-Up and Today’s Payments Ecosystem (with Gaurav Ahuja)

We sit down with Morgan Housel, who is one of our very favorite authors and has also become a good friend of the show over the past few years. Morgan’s last book The Psychology of Money had a huge impact on both of our personal financial philosophies (and by extension Acquired’s!), and Morgan was kind enough to give us an advance copy of his new book launching tomorrow, Same as Ever. It’s equally as good, and maybe even more relevant in the current environment for thinking about what’s not going to change as we cycle through vastly different macro financial environments. Tune in and enjoy! 
Links:Morgan’s new book Same as EverThe Psychology of MoneyMorgan’s blog on Collaborative Fund and on TwitterMorgan’s new podcast! Sponsors:Quartr


Morgan Housel

While preparing for our Porsche episode with Doug DeMuro, we had a lot more than Porsche to discuss… but the episode was already over 3 hours! We decided to save the rest for its own episode, released here on ACQ2. Doug helped us understand what’s going on with the car industry supply chain in 2023, the transition to electric vehicles, the car dealership business model, and how most consumer car purchase decisions really get made. We also got to talk with Doug about his business empire. In addition to his YouTube channel with ~5 million subscribers, Doug started a car marketplace called “Cars and Bids”. Earlier this year, Doug took a $37 million investment from The Chernin Group, and Doug walked us through that transaction and what it’s been like going from “indie creator” to a large and more professionalized organization. And of course, there’s some discussion on our Porsche episode together. Links:Cars and Bids!Doug on YouTube and Twitter Sponsors:Quartr


Doug Demuro on Analyzing the Car Industry, Creator-Led Businesses, and Porsche Episode Follow Up

We sit down with RunwayML’s CEO Cristobal Valenzuela to discuss the incredible tools they’re bringing to film and video creators (including last year’s Best Picture “Everything Everywhere All at Once” from A24), and the history + current state of the “visual” branch of generative AI. We cover how they’ve gone to market with both creators and enterprises, the potential for much more radical future use cases, and the company’s recent $141m strategic raise from Google, Nvidia + Salesforce and the context of the current AI fundraising landscape. Tune in! Links:RunwayFollow Cris on Twitter Sponsors:Quartr


Ben and David on "This Week in Startups" Holiday Special

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