The Brain Health Revolution Podcast

Beyond Heartburn: Probing the Association Between Proton Pump Inhibitor and Dementia


Listen Later

In this episode In this illuminating episode, we dive deep into the world of proton pump inhibitors (PPIs), commonly prescribed medications for heartburn and acid reflux. While these drugs have brought relief to millions worldwide, recent studies have begun to uncover potential links between PPI use and an increased risk of dementia. We explore the mechanisms that might underlie this association, the clinical implications for patients, and the broader question of how seemingly unrelated conditions might be connected at a molecular level. Whether you're a healthcare professional, a patient on PPIs, or simply someone curious about the intricate web of human health, this episode promises to offer fresh insights into a hotly debated area of medicine.

References:

Main papers disucssed in this episode:

- Northuis, Carin, et al. "Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study." Neurology (2023).

https://n.neurology.org/content/early/2023/08/09/WNL.0000000000207747?utm_source=twitter&utm_medium=organic

- Gomm, Willy, et al. "Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis." JAMA neurology 73.4 (2016): 410-416.

https://jamanetwork.com/journals/jamaneurology/article-abstract/2487379

- Li, Min, et al. "Proton pump inhibitor use and risk of dementia: systematic review and meta-analysis." Medicine 98.7 (2019).

- Ortiz-Guerrero, Gloria, et al. "Proton pump inhibitors and dementia: physiopathological mechanisms and clinical consequences." Neural plasticity 2018 (2018).

- Wijarnpreecha, Karn, et al. "Proton pump inhibitors and risk of dementia." Annals of translational medicine 4.12 (2016).

- Haenisch, Britta, et al. "Risk of dementia in elderly patients with the use of proton pump inhibitors." European archives of psychiatry and clinical neuroscience 265 (2015): 419-428.

- Batchelor, Riley, et al. "Dementia, cognitive impairment and proton pump inhibitor therapy: a systematic review." Journal of gastroenterology and hepatology 32.8 (2017): 1426-1435.

- Gray, Shelly L., et al. "Proton pump inhibitor use and dementia risk: Prospective population‐based study." Journal of the American Geriatrics Society 66.2 (2018): 247-253.

- Ahn, Nayeon, et al. "Do proton pump inhibitors increase the risk of dementia? A systematic review, meta‐analysis and bias analysis." British Journal of Clinical Pharmacology 89.2 (2023): 602-616.

Follow us:

Join the NEURO Academy: NEUROacademy.com

Follow us on social media:

Instagram: The Brain Docs @thebraindocs

Facebook: The Brain Docs

TikTok: @thebraindocs

Website: TheBrainDocs.com

 

...more
View all episodesView all episodes
Download on the App Store

The Brain Health Revolution PodcastBy Sherzai M.D.

  • 4.9
  • 4.9
  • 4.9
  • 4.9
  • 4.9

4.9

560 ratings


More shows like The Brain Health Revolution Podcast

View all
Nutrition Facts with Dr. Greger by Michael Greger, M.D. FACLM

Nutrition Facts with Dr. Greger

3,449 Listeners

NutritionFacts.org Video Podcast by Michael Greger, M.D. FACLM

NutritionFacts.org Video Podcast

852 Listeners

The mindbodygreen Podcast by mindbodygreen

The mindbodygreen Podcast

2,065 Listeners

The Plant Based News Podcast by Plant Based News

The Plant Based News Podcast

347 Listeners

Heart Doc VIP with Dr. Joel Kahn by Dr. Joel Kahn

Heart Doc VIP with Dr. Joel Kahn

475 Listeners

The Exam Room by the Physicians Committee by Physicians Committee

The Exam Room by the Physicians Committee

3,346 Listeners

Mastering Diabetes Audio Experience by Reverse insulin resistance permanently

Mastering Diabetes Audio Experience

649 Listeners

The Proof with Simon Hill by Live better for longer

The Proof with Simon Hill

2,600 Listeners

Dhru Purohit Show by Dhru Purohit

Dhru Purohit Show

3,500 Listeners

The Dr. Hyman Show by Dr. Mark Hyman

The Dr. Hyman Show

9,303 Listeners

Everyday Wellness with Cynthia Thurlow ™ by Everyday Wellness™

Everyday Wellness with Cynthia Thurlow ™

1,202 Listeners

Plant-Powered People Podcast by Toni Okamoto and Michelle Cehn

Plant-Powered People Podcast

388 Listeners

PLANTSTRONG Podcast by Rip Esselstyn

PLANTSTRONG Podcast

2,297 Listeners

Eat to Live by Jenna Fuhrman, Dr. Fuhrman

Eat to Live

555 Listeners

Your Brain On by Drs. Ayesha and Dean Sherzai

Your Brain On

275 Listeners