When you think of creatine you probably think about muscles, the gym, getting jacked. However, there's a new study that's looking at something totally different: creatine and cancer risk. We're gonna dive into this, break down what they found, and talk about what it actually means. Turns out, it's not as straightforward as you might think.

We cover the following topics:
00:00 - Intro
00:45 - Creatine Overview
03:15 - Study Overview
05:19 - Main Findings
07:24 - Mechanism of How This May Be
08:22 - Quartiles of Creatine Intake
10:24 - Subgroup Analysis
12:26 - Implications
13:54 - Limitations
16:26 - Making Sense Of It
16:58 - Outro

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

REFERENCES:

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this episode of the Building Lifelong Athletes podcast we talk about a meta analysis that looked at what exercise was best for improving type two diabetes.

We cover the following topics:
00:00 - Introduction
00:33 - Diabetes Overview
01:47 - Study Overview
02:18 - Understanding HbA1C
04:08 - Exercise and A1C: General Findings
04:36 - Marker 7
05:55 - What Type Of Exercise Is Best?
08:42 - Direct Comparisons
09:50 - Exercise Dosage
11:12 - Explaining METs
12:46 - Is More Better?
13:22 - Dose Specifics for Different Exercise
15:45 - Is HIIT King?
17:52 - Other Factors Affecting Findings
18:41 - Limitations
19:26 - Final Thoughts
21:18 - Outro

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

REFERENCES:

Liang, Z., Zhang, M., Wang, C., Hao, F., Yu, Y., Tian, S., & Yuan, Y. (2024). The Best Exercise Modality and Dose to Reduce Glycosylated Hemoglobin in Patients with Type 2 Diabetes: A Systematic Review with Pairwise, Network, and Dose–Response Meta-Analyses. Sports Medicine, 54(10), 2557–2570. https://doi.org/10.1007/s40279-024-02057-6  

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this episode of the Building Lifelong Athletes podcast we talk about apoB and why it is probably a better test than our standard lipid panel.

We cover the following topics
00:00 - Intro
00:40 - apoB Introduction
01:50 - apoB Structure and function
05:47 - apoB and atherosclerosis
07:29 - The Atherogenic Lipoprotein Particle Paradigm
11:14 - apoB Measurement in Practice
13:02 - apoB Target Goals
18:13 - apoB Treatment
19:51 - Arguments against apoB
23:22 - The Evidence Supporting apoB
26:43 - Conclusions
29:50 - Outro

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

REFERENCES:

Behbodikhah, J., Ahmed, S., Elyasi, A., Kasselman, L. J., De Leon, J., Glass, A. D., & Reiss, A. B. (2021). Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites, 11(10), 690. https://doi.org/10.3390/metabo11100690 De Oliveira-Gomes, D., Joshi, P. H., Peterson, E. D., Rohatgi, A., Khera, A., & Navar, A. M. (2024). Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice. Circulation, 150(1), 62–79. https://doi.org/10.1161/CIRCULATIONAHA.124.068885 Glavinovic, T., Thanassoulis, G., de Graaf, J., Couture, P., Hegele, R. A., & Sniderman, A. D. (2022). Physiological Bases for the Superiority of Apolipoprotein B Over Low‐Density Lipoprotein Cholesterol and Non–High‐Density Lipoprotein Cholesterol as a Marker of Cardiovascular Risk. Journal of the American Heart Association, 11(20), e025858. https://doi.org/10.1161/JAHA.122.025858 Li, C., Zhang, Y., Mei, L., Jin, A., Cai, X., Pan, Y., Jing, J., Wang, S., Meng, X., Li, S., Wang, M., Wei, T., Wang, Y., Chen, R., & Tian, Y. (2023). Discordantly high Apo B with LDL-C or non-HDL-C in relation to presence and burden of cerebral atherosclerotic plaques. Journal of Clinical Lipidology, 17(4), 519–528. https://doi.org/10.1016/j.jacl.2023.05.104 Sniderman, A. D., Thanassoulis, G., Glavinovic, T., Navar, A. M., Pencina, M., Catapano, A., & Ference, B. A. (2019). Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiology, 4(12), 1287. https://doi.org/10.1001/jamacardio.2019.3780 Soffer, D. E., Marston, N. A., Maki, K. C., Jacobson, T. A., Bittner, V. A., Peña, J. M., Thanassoulis, G., Martin, S. S., Kirkpatrick, C. F., Virani, S. S., Dixon, D. L., Ballantyne, C. M., & Remaley, A. T. (2024). Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association. Journal of Clinical Lipidology, 18(5), e647–e663. https://doi.org/10.1016/j.jacl.2024.08.013  

*Disclaimer*

This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Obesity isn't just about numbers on a scale or your BMI. It's a hidden epidemic silently fueling a range of diseases that we see every day. From heart failure and diabetes to Alzheimer's and even cancer, excess weight is a key player in about 70% of chronic diseases. Today, we expose the shocking truth about how obesity is hijacking our health and just how wide reaching this problem really is.

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:
00:00 - Intro
00:48 - Non-Communicable Diseases
02:28 - The Cost of Obesity
03:21 - Obesity Causes Disability and Early Death
06:27 - Overnutrition
08:30 - Obesity and Cardiovascular Disease
13:28 - Obesity and Lung Disease
14:43 - Obesity and Diabetes
17:12 - Obesity and Gastrointestinal Diseases
19:18 - Obesity and Neurologic Diseases
21:21 - Obesity and Cancer
22:55 - The Obesity Paradox
25:04 - Final Thoughts
28:05 - Outro

REFERENCES:

Hildebrand, S., & Pfeifer, A. (2025). The obesity pandemic and its impact on non-communicable disease burden. Pflügers Archiv - European Journal of Physiology. https://doi.org/10.1007/s00424-025-03066-8  

*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

In this episode of the Building Lifelong Athletes podcast, we discuss the pathophysiology, clinical presentation, and management of ganglion cysts.  

We cover the following topics:

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:
00:00 - Intro
00:42 - Pathophysiology
03:27 - Clinical Presentation
05:34 - Diagnosis
06:44 - Management
09:40 - Patient Considerations
11:04 - Conclusion

REFERENCES:

Gude, W., & Morelli, V. (2008). Ganglion cysts of the wrist: Pathophysiology, clinical picture, and management. Current Reviews in Musculoskeletal Medicine, 1(3–4), 205. https://doi.org/10.1007/s12178-008-9033-4  

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Peptides have become increasingly popular in recent years, with many people touting their benefits for healing and performance enhancement. One peptide that has gained a lot of attention is BPC-157. But what does the science actually say about this peptide?

In this episode of the Building Lifelong Athletes podcast, we dive into the research on BPC-157 and explore the potential risks and benefits of this peptide. We also discuss the hype surrounding BPC-157 and whether it lives up to the claims.

We cover the following topics:

If you are interested in learning more about BPC-157, then this episode is for you.

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:
00:00 - Intro
00:58 - What Are Peptides?
02:50 - What is BPC 157?
04:32 - Why Are These So Hyped Up?
08:04 - What Is The Human Research?
15:08 - What Are The Risks of BPC 157?
18:28 - What Are The Alternatives?
19:34 - Summary
23:35 - Outro

REFERENCES:

DeFoor, M. T., & Dekker, T. J. (2025). Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance? Arthroscopy : The Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International  Arthroscopy Association, 41(2), 150–152. https://doi.org/10.1016/j.arthro.2024.09.005

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and Tissue Research, 377(2), 153–159. https://doi.org/10.1007/s00441-019-03016-8

Lee, E., & Padgett, B. (2021). Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. Alternative Therapies in Health and Medicine, 27(4), 8–13.

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Big Pharma and Big Supplement: Are They Really That Different?   Uncover the shocking truths about the supplement industry and how it compares to Big Pharma.   Discover the dark side of supplements, from misleading marketing and pseudo-scientific claims to contamination and inconsistent dosing.   Finally, learn how to protect yourself and make informed decisions about supplements. 

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:
00:00 - Intro
01:10 - Big Pharma
14:22 - Supplement Industry Background
17:29 - Supplement Industry Dark Side
23:45 - Finances
25:13 - How To Find A Safe Supplement
28:36 - Conclusion

REFERENCES:

Cohen, P. A., Avula, B., Katragunta, K., Travis, J. C., & Khan, I. (2023). Presence and Quantity of Botanical Ingredients With Purported Performance-Enhancing Properties in Sports Supplements. JAMA Network Open, 6(7), e2323879. https://doi.org/10.1001/jamanetworkopen.2023.23879  

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Ben Patrick, better known as the @kneesovertoesguy has taken social media by storm. You’ve probably seen him doing some incredibly athletic feat that looks like it should be impossible to do, and all while making it look effortless. He has turned traditional rehabilitation on its head, helped thousands of people, and upset quite a few rehab professionals on the way. Today we are diving into what makes his programs so effective for lots of people, and stick around to the end as I’ll give you a practical checklist for what you need to look for when looking for a knee rehab program.

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:

00:00 - Intro
00:40 - Kneesovertoes Claims
02:14 - Why this program works for so many people
02:57 - Patient buy in
05:20 - Progressive Loading
11:29 - Autoregulation
15:13 - How To Pick A Program
22:17 - Summary
22:58 - Outro

REFERENCES:

https://www.youtube.com/c/thekneesovertoesguy

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

There is a mental health crisis in adolescents.. and it’s not getting better anytime soon unless we change something. Our kids are depressed and anxious and not performing their best in school… but what if there was a way to improve all of these things that doesn’t involve medications or therapy but rather exercise? In today’s podcast we will dive in to a recent study that looked at how exercise can affect all these things. And stick around to the end where I give the practical takeaways on what we can actually do to help our children succeed.

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life.
Click Here: www.jrennickemd.com

CHAPTERS:

00:00 - Intro
00:39 - The Study
04:27 - Why does motor fitness improve cognition?
06:49 - Better fitness = Better mood?
09:55 - The Screen Time Dilemma
12:05 - Practical Takeaways
15:36 - Outro

REFERENCES:

Haapala, E. A., Leppänen, M. H., Skog, H., Lubans, D. R., Viitasalo, A., Lintu, N., Jalanko, P., Määttä, S., & Lakka, T. A. (2024). Childhood Physical Fitness as a Predictor of Cognition and Mental Health in Adolescence: The PANIC Study. *Sports Medicine*. https://doi.org/10.1007/s40279-024-02107-z

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Do you worry too much about your health? Could it be possible that your concern for your health is actually making you less healthy? Today we are going to discuss an interesting article about health anxiety and how it may be worse for you than previously thought.

Sign up for my newsletter at www.jrennickemd.com

Timestamps:
00:00 - Start
00:12 - Article Intro
01:47 - Objective
02:03 - Study Design
03:24 - Outcomes
05:43 - Results
08:26 - Discussion
12:44 - Strengths/Limitations
14:09 - Real World Takeaways
20:46 - Outro

References:

Mataix-Cols, D., Isomura, K., Sidorchuk, A., Rautio, D., Ivanov, V. Z., Rück, C., Österman, S., Lichtenstein, P., Larsson, H., Kuja-Halkola, R., Chang, Z., Brickell, I., Hedman-Lagerlöf, E., & Fernández de la Cruz, L. (2024). All-Cause and Cause-Specific Mortality Among Individuals With Hypochondriasis. JAMA Psychiatry, 81(3), 284–291. https://doi.org/10.1001/jamapsychiatry.2023.4744  

*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Music from #Uppbeat (free for Creators!): https://uppbeat.io/t/prigida/sapphire License code: AUHWDOXKRX2HM2FJ