Autism Parenting Secrets

Clarify The Leucovorin Confusion


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Welcome to Episode 281 of Autism Parenting Secrets.

If you're a parent who’s heard about Leucovorin, folinic acid, or calcium folinate—and you're confused—you’re not alone. There's a lot of conflicting information right now, especially in the wake of the Leucovorin case and increased media attention.

This week’s guest returns to the podcast to help clarify what really matters. Nicole Rincon is a board-certified Physician Assistant, a microbiologist by training, and a deeply committed parent who’s been supporting children with autism—including her own triplets—for over a decade.

She brings both clinical and lived experience to this topic—and today, we dig into the nuances of folate metabolism, pharma vs supplement forms, and the specific use cases for Leucovorin and related supports.


The secret this week is…

Clarify The Leucovorin Confusion


You'll Discover:

  • Why Leucovorin Is Suddenly Getting National Attention (4:23)
  • Signs of Cerebral Folate Deficiency (8:11)
  • How To Know If Pharma Or Supplement-Based Support Is Right For Your Child (12:15)
  • Why Supporting The Folate Pathway Can Improve Speech, Focus, and Behavior (18:28)
  • What Parents Should Ask Before Starting Leucovorin (24:17)
  • Whether Leucovorin Is A Short-Term Fix Or Long-Term Support (33:13)


About Our Guest:


Nicole Rincon, MS, PA-C, is a board-certified Physician Assistant with a background in microbiology and genetics. She received her Master’s Degree from Western University of Health Sciences and has been working with children with autism—including her own triplets—for over a decade. Nicole offers functional and integrative care, combining deep clinical knowledge with personal insight.

🔗 More about Nicole at Rossignol Medical Center


References In This Episode:

  • The Folate Fix: Exploring the Role of Folate in Autism and Neurodevelopmental Disorders by Dr. Richard Frye
  • APS Episode 245: “Evidence-Based Treatments FIRST” w/ Dr. Richard Frye


Additional Resources:

  • To learn more about personalized 1:1 support, go to www.elevatehowyounavigate.com
  • Take The Quiz: What’s YOUR Top Autism Parenting Blindspot?


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Autism Parenting SecretsBy Len Arcuri, Cass Arcuri

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