Complex regional pain syndrome (CRPS) (a.k.a. RSD) is a chronic pain condition that may be caused by trauma, nerve injury, fracture, or surgery.CRPS has been known to be an extremely painful condition and they are severely restricted in almost all areas of life.These restrictions and the severe never-ending pain they live with day in and day out often leads to emotional distress such as depression, anxiety, anger, frustration, and hopelessness.Patients with CRPS have a higher risk of suicide compared to any other painful condition. One study on CRPS reported that 49.3% of patients with CRPS considered suicide and that the actual suicide attempt rate was 15.1%! Yet there may be a safe and effective answer! We discuss what can and what has been done successfully to treat this dread condition.