Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands

Conférence - Emmanuelle Passegué : Environmental Crosstalk and Bone Marrow Niche Regulation

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

In adult mammals, HSCs reside in the bone marrow (BM) cavity near diverse groups of stromal cells, which maintain the structural integrity of both bone and marrow microenvironments. Interactions among stromal cells and hematopoietic stem and progenitor cells modulate many of the critical functions of the hematopoietic system, including production of specific blood lineages and responses to infection and inflammation. Our understanding of these interactions has grown considerably with application of new technologies that have uncovered how cell populations associate in situ and exchange molecular signals. We will describe important architectural features of the BM cavity and its cellular composition and explore the central role of mesenchymal stromal cells (MSC) as organizers of hematopoietic niches.