Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

03 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et radiothérapie

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell Aging and Adaptation to Stress

Conférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell Production

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

Although young adult HSCs employ finely tuned mechanisms to balance pro-survival and stress responses, these maintenance strategies provoke vulnerabilities that manifest with continued age, leading to a decline in function. We will examine HSC biology through the lens of antagonistic pleiotropy, whereby the same mechanisms that are important for reproductive fitness form the basis for functional decline during aging. We will particularly highlight the central role of cell cycle regulation, niche cell reliance, inflammatory responses, cellular memory, and distinct metabolic regulation in driving HSC aging features, including expansion of the HSC pool, decreased self-renewal ability, myeloid-biased differentiation, and genomic instability leading to clonal hematopoiesis (CH) and leukemic transformation.

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands

Conférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell Production

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

Although highly regulated to maintain stable output of blood cells in health, the hematopoietic system is capable of extensive remodeling in response to external challenges, prioritizing production of certain blood cell types at the expense of others. We will consider how acute insults, such as infections and myeloablation, cause molecular, cellular, and metabolic changes in hematopoietic stem and progenitor cells at multiple levels of the hematopoietic hierarchy to drive accelerated production of mature myeloid cells needed to resolve the initiating insult. Moreover, we will discuss how dysregulation or subversion of these emergency myelopoiesis mechanisms contributes to the progression of chronic inflammatory diseases and solid cancer.

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands

Conférence - Emmanuelle Passegué : Environmental Crosstalk and Bone Marrow Niche Regulation

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

In adult mammals, HSCs reside in the bone marrow (BM) cavity near diverse groups of stromal cells, which maintain the structural integrity of both bone and marrow microenvironments. Interactions among stromal cells and hematopoietic stem and progenitor cells modulate many of the critical functions of the hematopoietic system, including production of specific blood lineages and responses to infection and inflammation. Our understanding of these interactions has grown considerably with application of new technologies that have uncovered how cell populations associate in situ and exchange molecular signals. We will describe important architectural features of the BM cavity and its cellular composition and explore the central role of mesenchymal stromal cells (MSC) as organizers of hematopoietic niches.

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

02 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et chimiothérapie

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal Demands

Conférence - Emmanuelle Passegué : Principle of Hematopoietic Stem Cell Biology and Blood Production

Emmanuelle Passegué

Directrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université Columbia

Résumé

Unlike most adult organs, the blood system regenerates continuously to maintain homeostasis in a life-long process orchestrated by a complex collection of hematopoietic stem and progenitor cells. Self-renewing HSCs reside at the apex of this hierarchy and produce all blood lineages, including the erythroid lineage that forms red blood cells, the megakaryocytic lineage that gives rise to platelets, and the myeloid and lymphoid lineages that generate cells of the innate and adaptive immune systems. Most HSCs exist in a quiescent state, dividing occasionally to self-renew and produce various lineage-biased multipotent progenitors that form a transit amplifying compartment sustaining the daily output of the blood system. We will consider how emerging concepts in cell differentiation and lineage priming are developing our understanding of the hematopoietic hierarchy and its functional attributes.

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2025-2026

01 - Stress oxydant et thérapeutiques anti-tumorales : principes généraux

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2024-2025

Colloque - Oxidative Stress in Cancer - Raphaël Rodriguez : Chemical Control of Cell Adaptation in Cancer and Immunity

Raphaël Rodriguez

Institut Curie, CNRS, INSERM

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2024-2025

Colloque - Oxidative Stress in Cancer - Marcus Conrad : Ferroptosis Modulation for Disease Prevention

Marcus Conrad

Helmholtz Zentrum München, Institute of Metabolism and Cell Death Neuherberg, Germany, Translational Redox Biology, Technical University of Munich (TUM), TUM Natural School of Sciences Garching, Germany

Hugues de Thé

Collège de France

Oncologie cellulaire et moléculaire

Année 2024-2025

Colloque - Oxidative Stress in Cancer - Raphaël Itzykson : Targeting Cystine Import in Acute Myeloid Leukemias

Raphaël Itzykson

Université Paris Cité, Assistance Publique – Hôpitaux de Paris