Moderator: Valentina Iuzzolino (Naples, Italy)

Guest: Elka Stefanova (Belgrade, Serbia) and Mamede de Carvalho (Lisbon, Porugal)

In this episode, Valentina Iuzzolino speaks with Elka Stefanova and Mamede de Carvalho about diagnostic challenges in amyotrophic lateral sclerosis and frontotemporal dementia. They discuss clinical heterogeneity, key differential diagnoses and red flags, the role of Gold Coast criteria and neurophysiology in ALS, and the importance of longitudinal clinical assessment and neuroimaging in distinguishing frontotemporal dementia from primary psychiatric disorders.