In this the fourth episode about Chiara Marletto's excellent work "The Science of Can and Can't" I discuss the science of information. Chapter 3 of the book is called "Information" but in this episode I do not actually read from the book. This is a broader overview of issues in epistemology, folk philosophy, physics and mathematics that have some connection to the topic of "information". I thought these might be useful contextual remarks before leaping into reading the book. That will happen next episode. Quite a few images and I move through a mathematical problem at one point on the screen which may be difficult given audio only. The video version is here: https://www.youtube.com/watch?v=s8uTVbdjMy8