In today’s episode, we’ll be discussing one of the most frequently discussed, and often debated, topics in preventive medicine, do statins influence the risk of dementia? You’ve probably heard some express concern that statins can cause memory loss or increase the risk of dementia, whereas others may emphasize the ability of statins to protect brain health. So what does the science really say? In this episode, we’ll explore the role of cholesterol in normal brain health, theoretical mechanisms explaining how statin therapy may cause harm as well as potential neurologic protection. We will then transition to review high quality evidence from randomized clinical trial, mendelian randomization, and even studies investigating those with genetic abnormalities resulting is exceedingly low levels of LDL throughout their lifetime genetic studies. And then most importantly, how this translates into practical decisions for those seeking to promote longevity and reduce their likelihood of dementia.

Blog Post and References:

https://kevinforeymd.com/statins-dementia/