In this week’s episode of The Menopause and Cancer Podcast, Dani speaks with two of the authors behind the new paper, Menopausal hormone therapy for breast cancer patients: what is the current evidence? Professor Jayant Vaidya, Consultant Oncoplastic Breast Surgeon, and Dr Sarah Glynne, GP and menopause specialist.

This is the first of a two-part special exploring what this new paper and upcoming MENO-ABC clinical trial could mean for breast cancer survivors curious about HRT or already on HRT.

Up until recently, most experts thought a study like this would never happen — but it’s happening.

Together, they unpack:

• What’s new about this paper — and why it matters.
• The scientific and ethical concept of equipoise (yes, Dani learned a new word!).
• How the new MENO-ABC trial could change what we know about HRT use after breast cancer.
• What this research might mean for patients, clinicians, and the future of survivorship care.

Next week: Don’t miss part two, where Dani and Dr Sarah Glynne take a deep dive into testosterone use after breast cancer — what we know, what we don’t, and where the conversation is heading.

Links & Resources:

The paper: https://journals.lww.com/menopausejournal/fulltext/9900/menopausal_hormone_therapy_for_breast_cancer.532.aspx

The trial: https://www.londonbreastcancer.com/meno-abc-trial

Find Dr Glynne here https://www.clairemellon.co.uk/dr-sarah-glynne

Find Professor Vaidya here https://professorvaidya.co.uk/

Watch Dani’s 5-part Youtube series on HRT after breast cancer, start here: https://www.youtube.com/watch?v=heTF5ufX59Y&list=PLsUEBZ4ZwowpAQ1ueFUHlzDvzAtD_hyQr&index=6

Episode Highlights:

00:00 Intro

08:01 "HRT Debate and Its Impact"

09:48 Evidence-Based Breast Cancer Trial

13:46 Advances in Breast Cancer Treatment

16:43 HRT Risks Post-Breast Cancer

20:52 Oestrogen Risks in Cancer Relapse

23:17 "Clinical Trial Equipoise Explained"

29:00 "Expert Consensus and Criticism"

29:47 Collaborative Review Strengthened Research

32:52 Breaking Shame Through Conversations

36:04 Weighing Risks for Quality Life

41:57 "Prioritising Quality Over Longevity"

43:08 HRT and Breast Cancer Relapse Risk

Read all about HRT after breast cancer in Dani’s book “Navigating Menopause After Cancer’ in chapter 6: Buy it here: https://amzn.eu/d/0uLveeE