In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Timothy Wilkin from the University of California San Diego about the human papillomavirus (HPV) and anal cancer with options for screening, prevention, and vaccination. 

They provide an overview of HPV and the types of HPV that lead to cancer. They discuss screening and prevention for anal cancer at HIV and PrEP clinics. They also discuss the findings of the ANCHOR study that demonstrated that high-resolution anoscopy screening detects and prevents anal cancer caused by HPV. Finally, they review HPV vaccination, its effectiveness, and the challenges with uptake of the vaccine in the population at large.

0:00 – Introduction

1:32 – Overview of HPV

3:01 – HPV and cancer

4:43 – Screening and prevention for anal cancer at HIV and PrEP clinics

9:38 – Findings of the ANCHOR study – efficacy of high resolution anoscopy in detecting anal cancer caused by HPV.

11:32 – Barriers to screening and treatment

15:05 – HPV vaccination - recommendations and efficacy 

18:10 – Challenges with HPV vaccination uptake

24:30 – Next ten years of HPV and closing remarks

Resources and articles:

Single dose HPV vaccine article
https://pubmed.ncbi.nlm.nih.gov/35693874/

ANCHOR trial
https://pubmed.ncbi.nlm.nih.gov/35704479/

CDC OI HPV guidelines
https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/human

International Anal Neoplasia Society (guidelines and HRA training)
https://www.iansoc.org

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Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email [email protected] to send feedback, show suggestions, or questions to be answered on a later episode.

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