Many environmental factors have been found to influence cardiovascular disease (CVD) risk, progression, and severity. Join Sanjay Rajagopalan, MD, FACC, FAHA, Chief of Cardiovascular Medicine at the University Hospitals, Harrington Heart & Vascular Institute, Director of Cardiovascular Research Institute at Herman K. Hellerstein MD, Professor of Cardiovascular Research, and Professor of the Department of Internal Medicine at Case Western Reserve University, as he is interviewed by Betul Hatipoglu MD, Professor of Medicine at CWRU School of Medicine, Vice-Chair at UH System Clinical Affairs, Department of Medicine, Medical Director of the Diabetes & Obesity Center at Mary B. Lee Chair in Adult Endocrinology, University Hospital Cleveland Medical Center, and Chair of the AACE Disease State Network Lipids & Cardiovascular Health. Dr. Rajagopalan and Dr. Hatipoglu discuss components of the environment that play an important role in health besides general lifestyle factors, including social, economic, and chemical pollutants.