Last week, at the American Academy of Neurology annual meeting, Dr. Amit Bar-Or received the John Dystel Prize for Multiple Sclerosis Research for his multiple achievements that have advanced our knowledge of neuroimmunology, precision medicine, and biomarkers in MS. We talked with Dr. Bar-Or about how some of the latest discoveries in MS research would impact patient care.

Tolebrutinib, an investigational disease-modifying therapy, is currently making its way through the FDA's regulatory process. Last week, the results of the Phase 3 clinical trials for Tolebrutinib were published, and we're sharing the details.

We'll also tell you about MindGlide, an AI-powered tool for analyzing MRI scans that will significantly reduce MRI exam times.

We're talking about the results of the Phase 3 clinical trial for high-dose Ocrevus.

And we'll tell you about a cell therapy that doesn't use stem cells that successfully repaired myelin in the mouse model of MS -- twice!

We have a lot to talk about! Are you ready for RealTalk MS??!

Congratulations to Dr. Stephen Hauser and Dr. Alberto Ascherio :22

This Week: The impact of breakthrough MS research on MS care 2:17

Results of the phase 3 clinical trials for Tolebrutinib have been published 3:07

An AI-powered tool for analyzing MRI scans will significantly reduce MRI exam times for patients 4:21

Results of the phase 3 clinical trial for high-dose Ocrevus 8:13

A cell therapy that doesn't use stem cells has successfully repaired myelin in the mouse model of MS -- twice! 10:14

Dystel Prize winner Dr. Amit Bar-Or discusses how some of the latest discoveries in MS research will impact MS care 12:39

Share this episode 22:36

Have you downloaded the free RealTalk MS app? 22:56

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LINKS

If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

Become an MS Activist Web: https://nationalmssociety.org/advocacy Email: [email protected]

RealTalk MS Episode 310: The Face Laughs While The Brain Cries: The Education of a Doctor with Dr. Stephen Hauser https://realtalkms.com/310

RealTalk MS ECTRIMS Extra: Results from the Phase 3 Clinical Trial for Tolebrutinib and Relapsing-Remitting MS with Dr. Jiwon Oh https://realtalkms.com/ectrims244

VIDEO: RealTalk MS ECTRIMS Extra: Results from the Phase 3 Clinical Trial for Tolebrutinib and Relapsing-Remitting MS with Dr. Jiwon Oh https://youtu.be/zcBmAHRTotA

VIDEO: RealTalk MS ECTRIMS Extra: Results from the Phase 3 Clinical Trial for Tolebrutinib and Nonrelapsing Secondary Progressive MS with Dr. Robert Fox https://youtu.be/tJQ93qdlXrU

STUDY: Tolebrutinib Versus Teriflunomide in Relapsing Multiple Sclerosis https://nejm.org/doi/full/10.1056/NEJMoa2415985

STUDY: Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis https://nejm.org/doi/full/10.1056/NEJMoa2415988

Enabling New Insights from Old Scans By Repurposing Clinical MRI Archives for Multiple Sclerosis Research https://www.nature.com/articles/s41467-025-58274-8

Fibroblast Technology https://fibrobiologics.com/technology/#cnsms

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RealTalk MS Episode 398 Guests: Dr. Amit Bar-Or

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