Voltando para a Clínica Médica, Raphael, Fred e Pedro discutem as características de cada anti-hipertensivo que utilizamos como primeira droga, soltando algumas clinicagens no meio do caminho. Faltou falar algo? Compartilha com a gente no nosso Instagram e Twitter @tadeclinicagem.

Minutagem:

[05:00] Aspectos para droga ser de primeira linha

[06:30] Quais são as drogas de primeira linha linha

[07:10] Tiazídicos

[13:00] Efeitos Colaterais dos Tiazídicos

[15:20] IECA/BRA

[16:40] Efeitos colaterais IECA/BRA

[21:55] Bloqueadores de Canais de Cálcio

[23:50] Efeitos colaterais dos BCC

[27:10] E o Beta-bloqueador?

[28:50] E os outros antihipertensivos?

[30:20] ALLHAT

[34:50] Monoterapia vs Duplaterapia

[36:50] Qual antihas vc prescreveria nessa situação?

[38:50] Salves

[41:45] Desafio da Semana Referências:

Furberg, Curt D., et al. "Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)." Journal of the American Medical Association 288.23 (2002): 2981-2997.

Jamerson, Kenneth, et al. "Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients." New England Journal of Medicine 359.23 (2008): 2417-2428.

Sociedade Brasileira de Cardiologia. "7ª Diretriz Brasileira de Hipertensão Arterial." Arquivos Brasileiros de Cardiologia 107.3 (2018).

Whelton, Paul K., et al. "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines." Journal of the American College of Cardiology 71.19 (2018): e127-e248.

Williams, Bryan, et al. "2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)." European heart journal 39.33 (2018): 3021-3104. UPTODATE 2020. Choice of drug therapy in primary (essential) hypertension. Johannes FE Mann. Meta-analysis of dose-response relationships for hydrochlorothiazide, chlorthalidone, and bendroflumethiazide on blood pressure, serum potassium, and urate.

CARLBERG, Bo; SAMUELSSON, Ola; LINDHOLM, Lars Hjalmar. Atenolol in hypertension: is it a wise choice? The Lancet, v. 364, n. 9446, p. 1684-1689, 2004.

UPTODATE March 2020 ACE inhibitor-induced angioedema. Authors:Autumn Chandler Guyer, MDAleena Banerji, M-D