Fred, Pedro, Rapha e João selecionaram quatro tópicos polêmicos de sepse para discutir nesse episódio! Um tema relevante para todos. Ficou com alguma dúvida, quer mandar alguma sugestão ou crítica? Entra em contato com a gente através do Instagram ou Twitter @tadeclinicagem ou e-mail [email protected]. Assina nossa Newsletter semanal com os temas mais interessantes da clínica médica! O link está disponível no Instagram e no Twitter.

MINUTAGEM

(03:35) Quick Sofa x SIRS

(14:35) Reposição volêmica

(26:40) Uso de corticoide

(32:42) Uso de vitamina C

(44:57) Salves

(47:02) Resposta do desafio anterior

(47:50) Desafio da semana

REFERÊNCIAS

1. FUJII, Tomoko et al. Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the vitamins randomized clinical trial. Jama, v. 323, n. 5, p. 423-431, 2020

2. DE GROOTH, Harm-Jan; ELBERS, Paul WG; VINCENT, Jean-Louis. Vitamin C for Sepsis and Acute Respiratory Failure. Jama, v. 323, n. 8, p. 792-792, 2020

3. TRUWIT, Jonathon D. et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. Jama, v. 322, n. 13, p. 1261-1270, 2019

4. CHANG, Ping et al. Combined treatment with hydrocortisone, vitamin C, and thiamine for sepsis and septic shock (HYVCTTSSS): A randomized controlled clinical trial. Chest, 2020

5. VENKATESH, Balasubramanian et al. Adjunctive glucocorticoid therapy in patients with septic shock. New England Journal of Medicine, v. 378, n. 9, p. 797-808, 2018.

6. ANNANE, Djillali et al. Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Intensive care medicine, v. 43, n. 12, p. 1751-1763, 2017.

7. ROCHWERG, Bram et al. Corticosteroids in sepsis: an updated systematic review and meta-analysis. Critical care medicine, v. 46, n. 9, p. 1411-1420, 2018

8. ANTAL, Oana, et al. "Initial Fluid Resuscitation Following Adjusted Body Weight Dosing in Sepsis and Septic Shock." The Journal of Critical Care Medicine 5.4 (2019): 130-135

9. SEYMOUR, Christopher W., et al. "Time to treatment and mortality during mandated emergency care for sepsis." New England Journal of Medicine 376.23 (2017): 2235-2244

10. OUELLETTE, Daniel R., and Sadia Z. Shah. "Comparison of outcomes from sepsis between patients with and without pre-existing left ventricular dysfunction: a case-control analysis." Critical Care 18.2 (2014): R79

11. RAJDEV, Kartikeya, et al. "Fluid resuscitation in patients with end-stage renal disease on hemodialysis presenting with severe sepsis or septic shock: A case control study." Journal of critical care 55 (2020): 157-162

12. BHATTACHARJEE, Poushali, Dana P. Edelson, and Matthew M. Churpek. "Identifying patients with sepsis on the hospital wards." Chest 151.4 (2017): 898-907

13. HAYDAR, Samir, et al. "Comparison of QSOFA score and SIRS criteria as screening mechanisms for emergency department sepsis." The American journal of emergency medicine 35.11 (2017): 1730-1733

14. JIANG, Jianjun, et al. "Head-to-head comparison of qSOFA and SIRS criteria in predicting the mortality of infected patients in the emergency department: a meta-analysis." Scandinavian journal of trauma, resuscitation and emergency medicine 26.1 (2018): 56

15. GOULDEN, Robert, et al. "qSOFA, SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis." Emerg Med J 35.6 (2018): 345-349