Pedro, Iago e Rapha debatem sobre 4 clinicagens sobre uma classe de medicamentos extremamente comum na prática: os corticoides. 1. Comp desmamar corticoide 2. Quais seus efeitos adversos 3. Quais os impactos dos corticoides na imunidade e 4. Existe alergia a corticoide?  

Minutagem

(5:25) Desmame do corticoide  

(18:17) Efeitos adversos do paciente em uso de corticoide 

(32:42) Infecção associadas ao corticoide  

(38:35) Existe alergia a corticoide? 

(44:00) Salves 

(47:20) Resposta desafio anterior (troponina) 

(48:22) Desafio dessa semana 

Gostou do episódio? Tem algum comentário para nós? Manda uma mensagem no @tadeclinicagem ou [email protected]. 

Referências

1. Glucocorticoid Withdrawl. Daniel E Furst. Kenneth G Saag. Uptodate Agosto 2020. 

2. HOCHBERG, Ze’ev; PACAK, Karel; CHROUSOS, George P. Endocrine withdrawal syndromes. Endocrine reviews, v. 24, n. 4, p. 523-538, 2003. 

3. TORNATORE, Kathleen M. et al. Pharmacokinetics of methylprednisolone in elderly and young healthy males. Journal of the American Geriatrics Society, v. 42, n. 10, p. 1118-1122, 1994. 

4. BYYNY, Richard L. Withdrawal from glucocorticoid therapy. New England Journal of Medicine, v. 295, n. 1, p. 30-32, 1976. 

5. DONALD, R. A. Dexamethasone suppression of the plasma corticosterone response to stress in the rat. The Journal of physiology, v. 182, n. 3, p. 603, 1966. 

6. FRASER, Charles G.; PREUSS, Fred S.; BIGFORD, Walter D. Adrenal atrophy and irreversible shock associated with cortisone therapy. Journal of the American Medical Association, v. 149, n. 17, p. 1542-1543, 1952. 

7. JOSEPH, Rebecca M. et al. Systemic glucocorticoid therapy and adrenal insufficiency in adults: a systematic review. In: Seminars in arthritis and rheumatism. WB Saunders, 2016. p. 133-141. 

8. VOLKMANN, Elizabeth R. et al. We still don’t know how to taper glucocorticoids in rheumatoid arthritis, and we can do better. 2013. 

9. RICHTER, Bernd; NEISES, Gudrun; CLAR, Christine. Glucocorticoid withdrawal schemes in chronic medical disorders: A systematic review. In: Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. Centre for Reviews and Dissemination (UK), 2002. 

10. Liu, Dora, et al. "A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy." Allergy, Asthma & Clinical Immunology 9.1 (2013): 30. 

11. Saag, Kenneth et al. Major side effects of systemic glucocorticoids. Uptodate.com acesso em 02/09/2020 

12 Harold N Rosenet al. Prevention and treatment of glucocorticoid-induced osteoporosis. Uptodate.com acesso em 02/09/2020