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How were decisions made about which treatments to trust before the advent of "evidence-based" medicine? How strong are biological arguments for or against various treatments? When did the Evidence-Based Medicine (EBM) movement begin? How did the EBM movement overcome initial resistance among medical professionals? What resources do doctors have at their disposals to find up-to-date information about treatment efficacies? Why is the pharmaceutical industry allowed such influence over information about treatments? What is the GRADE approach to EBM? What does EBM have to say about the role of patient preferences and values? How bad is being overweight? What are "surrogate" or "substitute" outcomes? How rigorous is the Diagnostic and Statistical Manual of Mental Disorders (DSM)? How often do treatments suffer from a lack of high-quality evidence of an effect versus plenty of high-quality evidence of a lack of an effect? What's the state of evidence about the placebo effect? What are the most exciting current initiatives in EBM?

Gordon Guyatt is a McMaster University Distinguished Professor. His work has focused on Evidence-Based Medicine and promoting high-quality healthcare without financial barriers for all Canadians. His Order of Canada citation acknowledges both contributions. He has been honored as a Canadian Institute of Health Research Researcher of the Year and a member of the Canadian Medical Hall of Fame. Learn more about Gordon and his work at clarityresearch.ca.

Further reading

• "This is why you shouldn’t believe that exciting new medical study" by Julia Belluz @ Vox

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• Spencer Greenberg — Host / Director
• Josh Castle — Producer
• Ryan Kessler — Audio Engineer
• Uri Bram — Factotum
• WeAmplify — Transcriptionists

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