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As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves.

Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost.

There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine.

In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy.

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0:00 Intro

5:35 The Scope of the Problem

8:09 Diabetic Neuropathy 

11:49 Neuropathy Following Chemotherapy 

14:21 Viral Infections: HIV Treatment & Covid

16:56 Why Mitochondria are Essential in This

19:44 Pharmaceutical Study of Neuropathy 

24:57 Aldose reductase inhibitor

29:31 Why This Approach is Different

37:44 How Antimuscarinics Work

48:10 Metrics for Getting FDA Approval

58:42 Funding the Research

1:01:53 Conclusion 

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