What is rhabdomyolysis?

Can it sneak under a clincian’s radar?

What the key clinical features?

When to be alert for rhabdomyolysis

Problems when coaches are too aggressive with a new load

Two cases – clinical scenarios

When sickle cell trait complicates matters

Which athlete with sickle cell trait is at increased risk?

Can clinicians identify the athlete with sickle cell trait who is at risk of death?

To screen or not to screen. Ethics and science.

Who is ready to return to play?

Who is at risk of recurrence? It applies to athletes and war fighters.

Role of genetics – the genetic markers that clinicians can test for in a tertiary care centre

Links to a previous podcast by Fran O’Connor – Exertional leg pain http://ow.ly/j9IU30bs1oe

Links to papers:

Sickle Cell paper in Medicine and Science in Sports and Exercise: https://www.ncbi.nlm.nih.gov/pubmed/?term=harmon+and+Med+Sci+Sports+Exerc

Pathophysiology of exertional death associated with sickle cell trait: can we make a parallel with vaso-occlusion mechanisms in sickle cell disease?

Connes P, Harmon KG, Bergeron MF.

http://bjsm.bmj.com/content/47/4/190.long

Sickle cell trait associated with a RR of death of 37 times in National Collegiate Athletic Association football athletes: a database with 2 million athlete-years as the denominator.

Harmon KG, Drezner JA, Klossner D, Asif IM.

http://bjsm.bmj.com/content/46/5/325.long

To screen or not to screen for sickle cell trait in American football?

Harmon KG, Drezner JA, Casa DJ.

http://bjsm.bmj.com/content/46/3/158.long

Return to Physical Activity After Exertional Rhabdomyolysis

O'Connor FG; Brennan FH, et al.