In this cutting-edge episode, Yosef Refaeli, Ph.D, co-founder and CEO
of Ascensus Therapeutics, reveals how a lab accident led to a
breakthrough in regenerative medicine that’s transforming longevity
and cancer treatment. From eliminating solid tumors to reversing
immune system aging and restoring vitality in humans (and even dogs),
Dr. Refaeli explains how harnessing the body’s own immune cells could
rewrite the future of health.
Whether you’re curious about revolutionary cancer therapies or how to
turn back your biological clock, this episode dives deep into the
science of staying “forever young.”
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In this episode, chemical and biotech engineer turned entrepreneur
Ashleigh DePopas, founder of Augie, shares how she created an
innovative at-home sizing kit to help women feel confident in their
breast augmentation decisions. From the outdated “rice test” to a
Warby Parker-style try-on experience, Ashleigh reveals how Augie is
empowering patients, improving surgeon consultations, and transforming
the way women choose their implant sizes.
Whether you’re considering breast augmentation or fascinated by
patient-driven medical innovation, this episode delivers practical
insight into technology, confidence, and choice in aesthetic surgery.
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In this powerful episode, former NFL quarterback Ryan Leaf opens up
about his meteoric rise to becoming the second overall draft pick, his
dramatic fall into addiction and incarceration, and the extraordinary
journey of redemption that followed. From walking out of prison with
nothing to becoming a mental health advocate, broadcaster, and devoted
father, Ryan shares how he transformed his mindset, rebuilt his
health, and found purpose through service and resilience.
Whether you're seeking inspiration to overcome adversity or insights
into wellness, mindset, and transformation, Ryan’s raw and uplifting
story is proof that it’s never too late to reinvent yourself.
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Can stem cells from your own fat heal your joints, reverse chronic pain—and have even saved a bomb-sniffing dog from being put down?

In this fascinating episode, veterinarian and stem cell pioneer Dr. Bob Harman explains how he has treated over 25,000 animals and is now bringing that regenerative magic to humans. From liposuctioning rhinos to FDA-approved stem cell trials in humans, Dr. Harman breaks down how fat-derived stem cells are changing the game in pain, inflammation, longevity, and even pet care. 

Whether you're curious about banking your own cells or healing your aging joints, this episode delivers eye-opening, science-backed insight.

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Could a century-old “blue goo” be the secret to younger, healthier skin? Top cosmetic surgeons Dr. John Layke and Dr. Payman Danielpour sit down with world-renowned aging expert and founder of Bluelene skincare Dr. Kan Cao to explore the science behind methylene blue—an under-the-radar antioxidant now making waves in the skincare and biohacking world.

Discover how this powerful molecule boosts collagen, rejuvenates tired mitochondria, and may even combat the dreaded “Ozempic face.” Backed by cutting-edge research and real clinical data, methylene blue is emerging as the retinol alternative for the future.

Whether you're a skincare junkie, longevity enthusiast, or just curious about the next-gen beauty frontier—this is one episode you can’t afford to miss.

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Drs. Layke and Danielpour welcome longevity scientist Dr. Chris Rhodes to discuss his breakthrough supplement, Mimio. Dr. Rhodes shares the science behind Mimio’s unique formulation, its clinical benefits, and exciting future research, including efforts to develop exercise-mimicking supplements.

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Drs. John and Dr. Payman explore the growing phenomenon of filler fatigue, break down the causes, offer natural-looking alternatives, and share expert tips on when to stop injecting and consider surgical or skin-focused solutions instead. Tune in for an honest conversation on evolving beauty trends, smart aesthetic choices, and how to stay confidently refreshed without going overboard.

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Drs. John and Payman sit down with research engineer and longevity expert Chris Burres, co-founder of MyVitalC and co-author of Live Longer and Better. Burres shares the incredible story behind ESS60, a Nobel Prize-winning molecule originally designed for industrial use that’s now gaining traction for its powerful antioxidant properties and potential to enhance energy, sleep, and healthy aging. Together, they dive deep into the science of oxidative stress, inflammation, and practical tools for living not just longer, but better.

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Drs. John and Paymansit down with renowned aging expert Dr. Matt Kaeberlein to explore the cutting edge of longevity science. From rapamycin and the Dog Aging Project to the promise and pitfalls of biohacking and caloric restriction. They unpack what it really takes to live not just longer, but better.

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Drs. Layke and Danielpour chat with Dr. Ashley Beckman, a specialist in Chinese medicine, epigenetics, and cellular detox. Together they talk about the root causes of chronic symptoms, from mold exposure to nervous system dysregulation, and how holistic detox and functional medicine can lead to real, lasting healing.

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