In this episode (watch on YouTube) we examine recent lab and animal research suggesting ivermectin — a widely used antiparasitic — can alter striatal circuits and enhance L-DOPA responses in preclinical Parkinson's models.

We'll explain the likely mechanisms (ion-channel modulation at P2X4 and nicotinic receptors), review safety concerns (blood-brain-barrier and neurotoxicity risks), and explain why there are no human trials yet proving efficacy in Parkinson's.

Sources and further reading are here:

1. Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function https://pubmed.ncbi.nlm.nih.gov/38632622/

2. Serious Neurological Adverse Events after Ivermectin https://pmc.ncbi.nlm.nih.gov/articles/PMC5929173/

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