This Week in Startups

Google’s AI Design Tool, Salesforce’s $8B Comeback Deal, and M&A Momentum Builds | E2131


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In this episode, we cover three major stories shaping the startup and tech landscape. First, Google unveils Stitch, an AI-powered web design tool with one-click export to Figma—signaling a major disruption for freelance design marketplaces. Then, Salesforce returns to M&A with its $8B acquisition of Informatica, aiming to broaden its AI data stack beyond CRM. Finally, we break down the surge in startup M&A activity, with billion-dollar deals from OpenAI, DoorDash, and others—hinting at a major Q2 rebound. Don’t miss Jason’s insights on what these trends mean for founders and investors.


(0:00) Episode Teaser

(1:36) Jason’s in SINGAPORE

(3:14) The Power of Shame and why we need “Ozempic for screentime”

(10:15) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/⁠twist

(12:38) Google’s latest AI breakthrough: Stitch

(20:13) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech

(21:20) The NBA on Polymarket and what founders can learn from the Knicks

(27:08) Why did Salesforce buy Informatica?

(30:03) Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.

(32:42) M&A activity continues, and Jason’s spicy Q2 predictions

(40:57) Did tech go woke or was it just performative the whole time?

(45:22) Circle, stablecoins, and the perks of being pro-business

(51:27) What Trump’s “golden share” of US Steel might look like

(54:15) Why Jason is bullish on Joby

(57:28) Episode wrap-up and upcoming events


Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


Links from episode:

ClearSpace App: https://www.getclearspace.com/

Google Stitch: https://stitch.withgoogle.com/

Joby: https://www.jobyaviation.com/



Follow Lon:

X: https://x.com/lons


Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis


Thank you to our partners:

(10:15) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/⁠twist

(20:13) CLA - Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconnect.com/tech

(30:03) Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.


Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


Check out Jason’s suite of newsletters: https://substack.com/@calacanis


Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com


Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916

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