This is part two of our podcast on regenerative medicine. In this episode Dr. Carrie Hardy joins Dr. Chris Hardy and Bill as they continue their discussion on PRP, exosomes, peptides, stem cells and whartons jelly. Also, they discuss sourcing on stem cells, wharton's jelly etc, how lifestyle impacts efficacy of the regenerative medicine, cost of peptides/stem cells/exosomes, how to find a clinic if you don't live in Washington, and a couple other questions.
Citations:
Fu X, Liu G, Halim A, Ju Y, Luo Q, Song AG. Mesenchymal Stem Cell Migration and Tissue Repair. Cells. 2019 Jul 28;8(8):784. doi: 10.3390/cells8080784. PMID: 31357692; PMCID: PMC6721499.
Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019 Aug 13;8(8):886. doi: 10.3390/cells8080886. PMID: 31412678; PMCID: PMC6721852.
Wan R, Hussain A, Behfar A, Moran SL, Zhao C. The Therapeutic Potential of Exosomes in Soft Tissue Repair and Regeneration. Int J Mol Sci. 2022 Mar 31;23(7):3869. doi: 10.3390/ijms23073869. PMID: 35409228; PMCID: PMC8998690.
Chang YH, Wu KC, Harn HJ, Lin SZ, Ding DC. Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy. Cell Transplant. 2018 Mar;27(3):349-363. doi: 10.1177/0963689717723636. Epub 2018 Apr 25. PMID: 29692195; PMCID: PMC6038041.
Main BJ, Maffulli N, Valk JA, Rodriguez HC, Gupta M, El-Amin SF 3rd, Gupta A. Umbilical Cord-Derived Wharton's Jelly for Regenerative Medicine Applications: A Systematic Review. Pharmaceuticals (Basel). 2021 Oct 27;14(11):1090. doi: 10.3390/ph14111090. PMID: 34832872; PMCID: PMC8618385.
Jiang S, Tian G, Yang Z, Gao X, Wang F, Li J, Tian Z, Huang B, Wei F, Sang X, Shao L, Zhou J, Wang Z, Liu S, Sui X, Guo Q, Guo W, Li X. Enhancement of acellular cartilage matrix scaffold by Wharton's jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration. Bioact Mater. 2021 Feb 13;6(9):2711-2728. doi: 10.1016/j.bioactmat.2021.01.031. PMID: 33665503; PMCID: PMC7895679.
Raeissadat SA, Ghazi Hosseini P, Bahrami MH, Salman Roghani R, Fathi M, Gharooee Ahangar A, Darvish M. The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial. BMC Musculoskelet Disord. 2021 Feb 3;22(1):134. doi: 10.1186/s12891-021-04017-x. PMID: 33536010; PMCID: PMC7860007.
Bennell KL, Paterson KL, Metcalf BR, Duong V, Eyles J, Kasza J, Wang Y, Cicuttini F, Buchbinder R, Forbes A, Harris A, Yu SP, Connell D, Linklater J, Wang BH, Oo WM, Hunter DJ. Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial. JAMA. 2021 Nov 23;326(20):2021-2030. doi: 10.1001/jama.2021.19415. PMID: 34812863; PMCID: PMC8611484. https://pubmed.ncbi.nlm.nih.gov/
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Dr. Hardy is a licensed physician and BJJ practitioner, but the contents of the podcast are meant for educational purposes only, and should not be taken as medical advice. Please seek out personalized care from your own medical provider prior to implementing any medical treatment or intervention.