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“How Close We Are to a Complete List of Imprinted Genes” by Morpheus
This post summarizes some of the research I have been doing for
Bootstrap Bio AKA kman and
Genesmith
TL;DR
important in human development, but further long-read sequencing in
adults and in the human placenta is going to get us close to that
goal.
annoying, because usually we can’t amplify methylated DNA. I explore
the only way that appears tractable to me to amplify methylated DNA
anyway. This could be useful for building an atlas of early embryo
development and for epigenetic preimplantation embryo screening.
sperm
Epigenetics and imprinting
This post assumes basic familiarity with epigenetics. The next paragraph
is a 1-paragraph summary, but I recommend reading
these
two
excellent posts on [...]
---
Outline:
(00:17) TL;DR
(00:56) Epigenetics and imprinting
(02:20) Why we need to know all imprinting regions and genes
(04:48) How imprinted genes work and how we measure them
(07:43) Have we identified all imprinted genes?
(12:39) Fixing paternal imprinting might be easier than fixing maternal imprinting
(13:15) PCR for methylated DNA
(17:11) Thoughts on the role of RNA in imprinting
(18:47) Some useful datasets and resources if someone else wants to look further into imprinting and epigenetics in the future
(20:57) References
The original text contained 11 footnotes which were omitted from this narration.
---
First published:
April 19th, 2025
Source:
https://www.lesswrong.com/posts/FX978FWaNQXeyat9S/how-close-we-are-to-a-complete-list-of-imprinted-genes
---
Narrated by TYPE III AUDIO.
---
Images from the article:
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
View all episodes
By LessWrongThis post summarizes some of the research I have been doing for
Bootstrap Bio AKA kman and
Genesmith
TL;DR
important in human development, but further long-read sequencing in
adults and in the human placenta is going to get us close to that
goal.
annoying, because usually we can’t amplify methylated DNA. I explore
the only way that appears tractable to me to amplify methylated DNA
anyway. This could be useful for building an atlas of early embryo
development and for epigenetic preimplantation embryo screening.
sperm
Epigenetics and imprinting
This post assumes basic familiarity with epigenetics. The next paragraph
is a 1-paragraph summary, but I recommend reading
these
two
excellent posts on [...]
---
Outline:
(00:17) TL;DR
(00:56) Epigenetics and imprinting
(02:20) Why we need to know all imprinting regions and genes
(04:48) How imprinted genes work and how we measure them
(07:43) Have we identified all imprinted genes?
(12:39) Fixing paternal imprinting might be easier than fixing maternal imprinting
(13:15) PCR for methylated DNA
(17:11) Thoughts on the role of RNA in imprinting
(18:47) Some useful datasets and resources if someone else wants to look further into imprinting and epigenetics in the future
(20:57) References
The original text contained 11 footnotes which were omitted from this narration.
---
First published:
April 19th, 2025
Source:
https://www.lesswrong.com/posts/FX978FWaNQXeyat9S/how-close-we-are-to-a-complete-list-of-imprinted-genes
---
Narrated by TYPE III AUDIO.
---
Images from the article:
Apple Podcasts and Spotify do not show images in the episode description. Try Pocket Casts, or another podcast app.
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