Hyperbaric oxygen therapy (HBOT) is a medical treatment in which patients breathe pure oxygen at higher than normal atmospheric pressure. This increases the amount of oxygen dissolved in body tissues, enabling tissue rejuvenation and accelerated recovery. Historically, HBOT has been used for chronic wounds like diabetic foot ulcers, radiation injuries, and non-healing surgical wounds. 

However, the research on HBOT is evolving and has recently suggested its use can have regenerative effects on the brain. At the forefront of this research is the Sagol Center in Israel, where scientists have shown that HBOT can also induce brain tissue regeneration and neuroplasticity, even years after brain injuries. These findings are expanding HBOT’s potential therapeutic uses for conditions like cognitive decline, traumatic brain injuries, stroke recovery, chronic pain, and other medical conditions. 

This episode of Longevity by Design features an exclusive interview with the founder and director of the Sagol Center, Dr. Shai Efrati. Dr. Efrati explains the science behind HBOT and how this treatment improves cognition. He details how oxygen fluctuations trigger the body's regenerative processes within the brain. He also underscores the importance of precision and exactness in using medical-grade equipment for this treatment, cautioning against the use of at-home hyperbaric oxygen therapies.

Timestamps

• Dr. Shai’s background (00:00-15:28)
• How exercise promotes angiogenesis (15:30-18:40)
• Commercialization of Hyperbaric oxygen therapy (HBOT) (18:40–24:40) 
• Health benefits of HBOT (24:40–31:31)
• Optimal HBOT protocol for improved cognition (31:32–37:22)
• Is HBOT beneficial for younger populations? (37:22–45:00)
• Can HBOT benefit individuals with impaired brain function? (45:01–50:40)
• Alzheimer's disease: Phenotypes and treatment (50:41–58:10)
• Top tip for brain health (58:10–end)

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