The Proof with Simon Hill

How to build a healthy gut using the latest microbiome science | Dr Suzanne Devkota


Listen Later

In this episode I sit down again with microbiome researcher Dr Suzanne Devkota to explore what a healthy microbiome really is and how we can support it. We unpack diversity, early life programming, fibre and microbiota accessible carbohydrates (MACs), plus the genuine role of probiotics, prebiotics and postbiotics.

Suzanne also shares cutting edge research on short chain fatty acids, Akkermansia, inflammatory bowel disease, visceral fat and colon cancer, and helps separate solid science from the noise you see online.

What We Cover

  • What the microbiome is and how it differs along the digestive tract
  • Why diversity is a key marker of gut health and how chronic disease and diet affect it
  • Early life influences on the microbiome, from birth mode to first foods
  • The realities of stool testing, different methods, and how to interpret results with care
  • Probiotics versus prebiotics versus postbiotics, when each may or may not be useful
  • MAC rich foods, short chain fatty acids and why butyrate is so important for gut barrier integrity
  • The Akkermansia story, mucus, leaky gut and why focusing on one bug is misleading
  • New data on IBD, gut leakiness, bacteria in fat tissue and links to fibrosis and metabolism
  • I hope this conversation gives you a clearer, more grounded view of gut health and helps you focus on practical, sustainable steps that genuinely support your microbiome.

    You can learn more from Dr Suzanne Devkota by following her on Instagram, or by visiting the Cedars-Sinai Human Microbiome Research Institute and the Devkota Lab.

    • Intro (00:00:00)
    • The Microbiome Conversation (00:01:16)
    • How Diversity Shapes Your Gut’s Health and Resilience (00:04:40)
    • The First Three Years That Shape a Lifetime (00:08:09)
    • What Microbiome Tests Can and Can’t Tell You (00:11:05)
    • Probiotics, Prebiotics, Postbiotics (00:18:05)
    • The Quiet Power of Short-Chain Fatty Acids (00:34:47)
    • The Fiber Controversy and What People Get Wrong (00:47:58)
    • How Daily Habits Quietly Reshape Your Microbiome (00:49:28)
    • Antibiotics, Resetting, and Rebuilding Your Gut (00:52:07)
    • How Early-Life Factors Imprint Your Gut for Decades (00:56:57)
    • Why Chronic Inflammation and IBD Connect Back to the Microbiome (01:03:14)
    • What We’re Learning About Colon Cancer and the Gut (01:16:13)
    • The Future of Microbiome Science and Personalized Gut Care (01:27:45)
    • This episode is brought to you by:

      38TERA

      Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

      Function Health

      Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

      Eight Sleep

      Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $400 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping.

      Momentous

      My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

      Simon Hill, MSc, BSc (Hons)

      • Creator of theproof.com
      • Host of The Proof with Simon Hill
      • Author of The Proof is in the Plants
      • Subscribe & Connect:

        • YouTube
        • Apple Podcasts
        • Spotify
        • Instagram: @simonhill
        • Twitter: @theproof
        • Facebook: The Proof with Simon Hill
        • ...more
          View all episodesView all episodes
          Download on the App Store

          The Proof with Simon HillBy Live better for longer

          • 4.9
          • 4.9
          • 4.9
          • 4.9
          • 4.9

          4.9

          2,503 ratings


          More shows like The Proof with Simon Hill

          View all
          The Rich Roll Podcast by Rich Roll

          The Rich Roll Podcast

          11,880 Listeners

          Nutrition Facts with Dr. Greger by Michael Greger, M.D. FACLM

          Nutrition Facts with Dr. Greger

          3,457 Listeners

          NutritionFacts.org Video Podcast by Michael Greger, M.D. FACLM

          NutritionFacts.org Video Podcast

          883 Listeners

          The Exam Room by the Physicians Committee by Physicians Committee

          The Exam Room by the Physicians Committee

          3,397 Listeners

          The Neuro Experience by Louisa Nicola & Pursuit Network

          The Neuro Experience

          435 Listeners

          The Doctor's Kitchen Podcast by Dr Rupy Aujla

          The Doctor's Kitchen Podcast

          631 Listeners

          Feel Better, Live More with Dr Rangan Chatterjee by Dr Rangan Chatterjee: GP & Author

          Feel Better, Live More with Dr Rangan Chatterjee

          3,862 Listeners

          The Genius Life by Max Lugavere

          The Genius Life

          4,915 Listeners

          Dhru Purohit Show by Dhru Purohit

          Dhru Purohit Show

          3,498 Listeners

          The Dr. Hyman Show by Dr. Mark Hyman

          The Dr. Hyman Show

          9,286 Listeners

          The Peter Attia Drive by Peter Attia, MD

          The Peter Attia Drive

          8,621 Listeners

          PLANTSTRONG Podcast by Rip Esselstyn

          PLANTSTRONG Podcast

          2,325 Listeners

          Huberman Lab by Scicomm Media

          Huberman Lab

          29,253 Listeners

          ZOE Science & Nutrition by ZOE

          ZOE Science & Nutrition

          2,140 Listeners

          The Dr. Gabrielle Lyon Show by Dr. Gabrielle Lyon

          The Dr. Gabrielle Lyon Show

          1,207 Listeners